--- title: Does danazol help premenstrual tension symptoms? | Niyora description: Danazol may help some symptoms better than placebo, particularly breast pain, lethargy, anxiety and increased appetite by the third month. However, 13 of 40 w url: https://niyora.com/research/papers/a-clinical-trial-using-danazol-for-the-treatment-of-premenstrual-tension-1987/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does danazol help premenstrual tension symptoms? Randomised trial, 1987 # Does danazol help premenstrual tension symptoms? Danazol may help some symptoms better than placebo, particularly breast pain, lethargy, anxiety and increased appetite by the third month. However, 13 of 40 women dropped out during the study, mostly because they felt the treatment was not helping. Early or limited evidence 40 women with premenstrual tension ## What they did Forty women with premenstrual tension were randomly assigned to receive placebo or 100, 200, or 400 mg danazol daily for 3 months in a double-blind pilot study. ## What they found Thirteen patients withdrew by the third month due to lack of improvement. In danazol-treated women, breast pain, irritability, anxiety and lethargy were significantly lower in months 2-3 compared to placebo. Most placebo symptoms improved in month 1 but only 3 remained improved by month 3. Eight symptoms improved on 200 mg danazol by month 3. More than 75% of women still taking danazol were free of breast pain, lethargy, anxiety and increased appetite. Results for other symptoms were no better than placebo. ## What it means for you Danazol may reduce some premenstrual symptoms better than placebo by the third month. However, a substantial number of women (13 out of 40) did not see improvement and stopped the study, and the benefit was only clear for a few symptoms. 8 Symptoms improved on 200 mg danazol by month 3 >75% Free of major symptoms on danazol 13 Women who withdrew ## About the study Original title A clinical trial using danazol for the treatment of premenstrual tension Authors Watts JF, Butt WR, Logan Edwards R Journal British journal of obstetrics and gynaecology Year 1987 Study design Randomised trial What was tested Placebo or 100, 200, or 400 mg danazol daily for 3 months Read the paper [doi.org/10.1111/j.1471-0528.1987.tb02248.x](https://doi.org/10.1111/j.1471-0528.1987.tb02248.x) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Fatigue and energy](https://niyora.com/research/topics/symptom-fatigue/)[Bloating, breast tenderness and physical symptoms](https://niyora.com/research/topics/symptom-physical-symptoms/)[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)[Eating disorders](https://niyora.com/research/topics/comorbidity-eating-disorders/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Systematic review, 2021 Does damask rose help reduce menstrual pain, headache, fatigue, anxiety, and bloating? Case-control study, 2025 Do women with eating disorders experience more menstrual distress, and does birth control help? Randomised trial, 2021 Does hypnotherapy reduce pain and emotional distress in women with PMDD? Randomised trial, 2018 Does swimming reduce premenstrual syndrome symptoms? Survey study, 2016 Do hormonal contraceptives reduce PMS symptoms? Survey study, 1982 How common are premenstrual symptoms in American women, and what factors affect them? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗