---
title: What is GnRH and what is it used for in women? | Niyora
description: GnRH is a hormone medication that stops the release of other hormones involved in ovulation. It is used to treat PMS, endometriosis, fibroids, and other condi
url: https://niyora.com/research/papers/a-clinician-s-guide-to-the-use-of-gonadotropin-releasing-hormone-analogues-in-2000/
---

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- What is GnRH and what is it used for in women?

Review, 2000

# What is GnRH and what is it used for in women?

GnRH is a hormone medication that stops the release of other hormones involved in ovulation. It is used to treat PMS, endometriosis, fibroids, and other conditions.

 Early or limited evidence

Not a study of specific people; a clinical guide article

## What they did

This is a clinical review article explaining how GnRH medications work and their uses in medical practice.

## What they found

GnRH agonists initially stimulate hormone release, then suppress the pituitary-gonadal axis. GnRH antagonists directly suppress hormones without the initial stimulation. Both are useful for multiple clinical indications including endometriosis, fibroids, hirsutism, irregular bleeding, and premenstrual syndrome.

## What it means for you

GnRH medications can be used for PMS when other treatments fail, but this is a review of how the medications work rather than evidence from a clinical trial. It does not describe specific benefits or side effects for PMS specifically.

1971

Year GnRH was identified and synthesized

## About the study

Original title A clinician's guide to the use of gonadotropin-releasing hormone analogues in women Authors Moghissi KS Journal Medscape women's health Year 2000 Study design Review What was tested GnRH agonists and GnRH antagonists Read the paper [https://pubmed.ncbi.nlm.nih.gov/10792849/](https://pubmed.ncbi.nlm.nih.gov/10792849/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)[Endometriosis](https://niyora.com/research/topics/comorbidity-endometriosis/)

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## Related studies

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How should severe period pain in teenagers be treated?

Survey study, 2002

What causes period pain, endometriosis, and PMS in teenage girls, and what treatments work?

Non-randomised trial, 2002

Is it safe to use hormone therapy alongside GnRH-agonist treatment for severe PMS?

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