---
title: Does paroxetine help premenstrual tension syndrome? | Niyora
description: Yes. Paroxetine greatly reduced depression, anxiety, and physical symptoms over 3 months, much more than vitamin B1 did.
url: https://niyora.com/research/papers/a-control-study-on-the-treatment-of-premenstrual-tension-syndrome-with-2005/
---

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- Does paroxetine help premenstrual tension syndrome?

Study, 2005

# Does paroxetine help premenstrual tension syndrome?

Yes. Paroxetine greatly reduced depression, anxiety, and physical symptoms over 3 months, much more than vitamin B1 did.

 Moderate study design

Women with premenstrual tension syndrome

## What they did

Randomized controlled study comparing paroxetine treatment to vitamin B1 treatment in women with premenstrual tension syndrome. Doctors measured mood and physical symptoms at baseline and after 3 months using rating scales.

## What they found

Women taking paroxetine had depression symptoms reduce by 63.2%, anxiety by 57.3%, and physical symptoms by 57.8%. Women taking vitamin B1 had much smaller reductions: depression by 10.2%, anxiety by 9.7%, and physical symptoms by 6.9%. The difference between groups was clear.

## What it means for you

Paroxetine works much better than vitamin B1 for premenstrual tension syndrome symptoms. Main limits are the abstract does not specify how many women were studied and does not describe how long benefits lasted after the study ended.

63.2%

Depression symptom reduction with paroxetine

57.3%

Anxiety symptom reduction with paroxetine

57.8%

Physical symptom reduction with paroxetine

## About the study

Original title A control study on the treatment of premenstrual tension syndrome with paroxetine Authors 王相立, 麻爱华 Journal Zhonghua xingwei yixue yu naokexue zazhi Year 2005 Study design Study What was tested Paroxetine (an antidepressant) compared to vitamin B1 Read the paper [doi.org/10.3760/cma.j.issn.1005-8559.2005.08.010](https://doi.org/10.3760/cma.j.issn.1005-8559.2005.08.010)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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