--- title: Does a B6 supplement with herbs help sleep and anxiety in PMS and menopause? description: Yes, the supplement improved sleep problems by 46.6% and anxiety by 23.2% in women with PMS and those in menopause transition. url: https://niyora.com/research/papers/a-dietary-supplement-of-vitamin-b6-with-four-herbal-extracts-improves-sleep-2022/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does a B6 supplement with herbs help sleep and anxiety in PMS and menopause? Randomised trial, 2022 # Does a B6 supplement with herbs help sleep and anxiety in PMS and menopause? Yes, the supplement improved sleep problems by 46.6% and anxiety by 23.2% in women with PMS and those in menopause transition. Early or limited evidence 32 women aged 18-70 (18 with PMS, 14 with menopause transition) with sleep disturbances and anxiety ## What they did Exploratory prospective study with 32 women (18 with PMS, 14 with menopause transition) aged 18-70 with sleep disturbances and anxiety. They took one tablet containing vitamin B6 and four plant extracts twice daily for 15-20 days. Sleep was measured with the Insomnia Severity Index and anxiety with the Hospital Anxiety and Depression Scale. ## What they found In all participants, sleep scores improved by 46.6% (from 20.39 to 10.87) and anxiety scores improved by 23.2% (from 16.23 to 12.45) from baseline to end of treatment. Improvements were seen in both women with PMS and those in menopause transition. ## What it means for you The supplement showed promise for helping sleep and anxiety. However, this small study had no control group, so improvements might be natural recovery or placebo effect. Larger controlled studies are needed to confirm effectiveness. 32 Women completed the study 46.6% Improvement in sleep scores 23.2% Improvement in anxiety scores ## About the study Original title A Dietary Supplement of Vitamin B6 with Four Herbal Extracts Improves Sleep Disturbances and Anxiety Associated with the Menstrual Cycle and Menopause Transition: Results from an Exploratory Study Authors Franco Vicariotto, Anna Porchetti, Filippo Murina Journal Integrative and Complementary Therapies Year 2022 Study design Randomised trial Participants 18 What was tested Vitamin B6 supplement with four herbal extracts, one tablet twice daily for 15-20 days Read the paper [doi.org/10.1089/ict.2022.29051.fvi](https://doi.org/10.1089/ict.2022.29051.fvi) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Sleep and insomnia](https://niyora.com/research/topics/symptom-sleep/)[Diet and nutrition](https://niyora.com/research/topics/treatment-diet/)[Vitamin B6](https://niyora.com/research/topics/treatment-vitamin-b6/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/)[Perimenopause and menopause](https://niyora.com/research/topics/comorbidity-perimenopause/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Review, 2023 Can herbs and supplements help with PMS symptoms? Randomised trial, 2024 Does a supplement with Rhodiola, Vitex, and vitamin B6 reduce PMS? Survey study, 2012 What non-hormonal medications and therapies help severe PMS and PMDD? Randomised trial, 2000 Does magnesium and vitamin B6 together help with anxiety-related premenstrual symptoms? Survey study, 2026 Can changing your diet help with period and PMS symptoms like fatigue, mood swings and bloating? Study, 2026 How can lifestyle changes help reduce premenstrual syndrome? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗