--- title: Does magnesium and vitamin B6 together help with anxiety-related premenstrual symptoms? description: A combination of 200 mg magnesium plus 50 mg vitamin B6 daily showed a small benefit for anxiety-related symptoms like nervousness and mood swings. Individual url: https://niyora.com/research/papers/a-synergistic-effect-of-a-daily-supplement-for-1-month-of-200-mg-magnesium-plus-2000/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does magnesium and vitamin B6 together help with anxiety-related premenstrual symptoms? Randomised trial, 2000 # Does magnesium and vitamin B6 together help with anxiety-related premenstrual symptoms? A combination of 200 mg magnesium plus 50 mg vitamin B6 daily showed a small benefit for anxiety-related symptoms like nervousness and mood swings. Individual supplements alone did not work. Moderate study design 44 women (average age 32) with mild premenstrual symptoms ## What they did 44 women with an average age of 32 took all four treatments one at a time for one menstrual cycle each: magnesium alone (200 mg), vitamin B6 alone (50 mg), both together, and placebo. They kept daily records of 30 symptoms. ## What they found Neither magnesium nor vitamin B6 alone made a significant difference. The combination of 200 mg magnesium plus 50 mg vitamin B6 did reduce anxiety-related symptoms (nervous tension, mood swings, irritability, anxiety). The effect was small. Magnesium absorption appeared poor. ## What it means for you The combination might help mildly with anxiety symptoms, but the effect is small. Only one month of treatment was tested, and the researchers said longer supplementation might work better since absorption was poor. More research is needed. 44 women studied 200 mg magnesium in combination dose 50 mg B6 in combination dose ## About the study Original title A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study Authors De Souza MC, Walker AF, Robinson PA et al. Journal Journal of women's health & gender-based medicine Year 2000 Study design Randomised trial Participants 44 What was tested 200 mg magnesium, 50 mg vitamin B6, both combined, or placebo, each for one menstrual cycle Read the paper [doi.org/10.1089/152460900318623](https://doi.org/10.1089/152460900318623) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Irritability and anger](https://niyora.com/research/topics/symptom-irritability-anger/)[Diet and nutrition](https://niyora.com/research/topics/treatment-diet/)[Magnesium](https://niyora.com/research/topics/treatment-magnesium/)[Vitamin B6](https://niyora.com/research/topics/treatment-vitamin-b6/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Review, 2023 Can herbs and supplements help with PMS symptoms? Survey study, 2026 Can changing your diet help with period and PMS symptoms like fatigue, mood swings and bloating? Study, 1983 Does nutrition affect premenstrual symptoms? Review, 2026 Can diet and nutrition help reduce PMS symptoms? Review, 2025 Do yoga and dietary changes help with PMS symptoms? Survey study, 2025 Do certain nutrients and body weight affect PMS? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗