---
title: Does zinc supplementation help with PMS symptoms? | Niyora
description: Yes. Zinc supplements significantly reduced physical symptoms, anger, anxiety, tearfulness, difficulty concentrating, insomnia, and overeating compared to pla
url: https://niyora.com/research/papers/a-systematic-review-and-meta-analysis-examining-the-role-of-zinc-supplementation-2025/
---

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- Does zinc supplementation help with PMS symptoms?

Systematic review, 2025

# Does zinc supplementation help with PMS symptoms?

Yes. Zinc supplements significantly reduced physical symptoms, anger, anxiety, tearfulness, difficulty concentrating, insomnia, and overeating compared to placebo.

 Strong study design

Young females with PMS (5 randomized controlled trials)

## What they did

Meta-analysis of 5 randomized controlled trials examining zinc supplementation versus placebo in females with PMS. Electronic repositories were searched until May 2023 to identify eligible studies.

## What they found

Zinc improved physical health (MD: 3.69) and reduced physical symptoms (MD: -0.79). Zinc also significantly decreased anger (p=0.005), anxiety (p=0.04), tearfulness (p<0.0001), difficulty concentrating (p=0.02), insomnia (p<0.00001), hypersomnia (p=0.006), feeling overwhelmed (p=0.05), and overeating (p=0.0003).

## What it means for you

Zinc appears effective for multiple PMS symptoms including emotional symptoms and sleep problems. The main limitation is that only 5 studies were included, so results need confirmation in larger studies.

5

randomized trials

3.69

physical health improvement

-0.79

physical symptom reduction

## About the study

Original title A systematic review and meta-analysis examining the role of zinc supplementation in ameliorating physical and psychological manifestations of premenstrual syndrome in young females Authors Haider S, Sajjad M, Zahid M Journal European journal of obstetrics, gynecology, and reproductive biology Year 2025 Study design Systematic review What was tested Zinc supplementation compared to placebo Read the paper [doi.org/10.1016/j.ejogrb.2025.114082](https://doi.org/10.1016/j.ejogrb.2025.114082)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Cognition, concentration and memory](https://niyora.com/research/topics/symptom-cognition/)[Zinc and iron](https://niyora.com/research/topics/treatment-zinc-iron/)

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