--- title: Can high testosterone levels be connected to PMDD, bipolar disorder, and certain medications? description: In one woman with bipolar disorder and PMDD on quetiapine and lithium, initial testosterone was 88.5 ng/dL. When hormone levels were normalized, testosterone url: https://niyora.com/research/papers/affective-disorder-and-hyperandrogenism-2013/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Can high testosterone levels be connected to PMDD, bipolar disorder, and certain medications? Case report, 2013 # Can high testosterone levels be connected to PMDD, bipolar disorder, and certain medications? In one woman with bipolar disorder and PMDD on quetiapine and lithium, initial testosterone was 88.5 ng/dL. When hormone levels were normalized, testosterone returned to normal. This is one case only. Early or limited evidence One 40-year-old woman with bipolar disorder and PMDD ## What they did A case report of one 40-year-old woman with bipolar disorder and PMDD being treated with quetiapine and lithium carbonate. Doctors tested her hormone levels including testosterone, thyroid hormone, and progesterone. ## What they found Her testosterone was initially high at 88.5ng/dL. After her hormone levels were balanced, free testosterone was 0.20 pg/ml and total testosterone was 27.90ng/dl. Her free thyroxine was 0.83ng/dl and her progesterone was 3.80ng/ml. ## What it means for you The paper suggests there may be a connection between high testosterone, the medications being taken, bipolar disorder, and PMDD. However, this is just one woman and the abstract doesn't explain what was done to normalize her hormones. More research would be needed to understand if there are real connections between these conditions and medications. 88.5 ng/dL initial testosterone 27.90 ng/dl final total testosterone 40 years age ## About the study Original title Affective disorder and hyperandrogenism Authors Zerouni C, Kummerow E, Martinez M et al. Journal Recent patents on endocrine, metabolic & immune drug discovery Year 2013 Study design Case report What was tested Quetiapine and lithium carbonate (method for normalizing hormones not specified) Read the paper [doi.org/10.2174/187221413804660917](https://doi.org/10.2174/187221413804660917) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiolytics and other psychotropics](https://niyora.com/research/topics/treatment-anxiolytics/)[Bipolar disorder](https://niyora.com/research/topics/comorbidity-bipolar/)[Schizophrenia and psychosis](https://niyora.com/research/topics/comorbidity-psychosis/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Case report, 2013 Can severe mood changes around a period be an early sign of bipolar disorder? Review, 2002 What treatments work best for PMS and PMDD? Study, 2026 Do anxiety and depression get worse before your period if you already have a mental health condition? Survey study, 2026 What is the true rate of PMDD, and does it worsen mental health conditions? Systematic review, 2025 What are the main trends in research about premenstrual disorders and related conditions? Cohort study, 2011 Does premenstrual symptom worsening change how bipolar disorder develops over time? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗