---
title: Are hormone levels different in women with PMS? | Niyora
description: Yes, women with PMS had significantly lower progesterone and allopregnanolone levels during the follicular phase of their cycle compared to controls.
url: https://niyora.com/research/papers/allopregnanolone-in-women-with-premenstrual-syndrome-1998/
---

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- Are hormone levels different in women with PMS?

Case-control study, 1998

# Are hormone levels different in women with PMS?

Yes, women with PMS had significantly lower progesterone and allopregnanolone levels during the follicular phase of their cycle compared to controls.

 Early or limited evidence

Women with PMS and control women (sample size not specified)

## What they did

Case-control study measuring levels of the progesterone metabolites allopregnanolone and progesterone in women with PMS and control women.

## What they found

Significantly lower levels of both progesterone and allopregnanolone were found in PMS patients in the follicular phase only.

## What it means for you

This suggests women with PMS may process progesterone differently than others, at least during the first part of their menstrual cycle. However, the abstract does not provide the specific values of these levels or state how many women were studied, which limits what we can conclude.

## About the study

Original title Allopregnanolone in women with premenstrual syndrome Authors Bicíková M, Dibbelt L, Hill M et al. Journal Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme Year 1998 Study design Case-control study What was tested None (observational measurement study) Read the paper [doi.org/10.1055/s-2007-978871](https://doi.org/10.1055/s-2007-978871)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Neurosteroids (allopregnanolone)](https://niyora.com/research/topics/treatment-neurosteroids/)[Pregnancy and postpartum](https://niyora.com/research/topics/comorbidity-postpartum/)

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