---
title: Do women with PMS have different serotonin levels in their blood?
description: Blood samples from women with PMS showed different patterns of serotonin uptake compared to women without PMS, suggesting there may be differences in blood ch
url: https://niyora.com/research/papers/alteration-of-5-ht-uptake-by-plasma-fractions-in-the-premenstrual-syndrome-1990/
---

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- Do women with PMS have different serotonin levels in their blood?

Case-control study, 1990

# Do women with PMS have different serotonin levels in their blood?

Blood samples from women with PMS showed different patterns of serotonin uptake compared to women without PMS, suggesting there may be differences in blood chemistry. However, this lab study looked at isolated blood cells, not actual PMS symptoms in living women.

 Early or limited evidence

Women with PMS and healthy control women

## What they did

Case-control lab study comparing blood plasma from women with PMS and healthy controls to see how well serotonin is taken up by blood cells and brain tissue

## What they found

Plasma from women with PMS caused less stimulation of serotonin uptake in blood platelets compared to controls. Premenstrual plasma from women with PMS more strongly inhibited serotonin uptake than plasma from women without PMS. In brain tissue samples, there were no significant differences between groups.

## What it means for you

This lab study found differences in how blood platelets handle serotonin in women with PMS, but these same differences were not found in brain tissue samples. Since this is isolated cells in a lab, not measurements of real PMS symptoms in living women, the practical significance is unclear.

## About the study

Original title Alteration of 5-HT uptake by plasma fractions in the premenstrual syndrome Authors Ashby CR Jr, Carr LA, Cook CL et al. Journal Journal of neural transmission. General section Year 1990 Study design Case-control study What was tested None; observational lab study of blood chemistry Read the paper [doi.org/10.1007/bf01250999](https://doi.org/10.1007/bf01250999)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)

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