---
title: Are brain network connections different in women with PMS? | Niyora
description: Yes. Women with PMS showed different brain network organization than healthy women, with changes in areas involved in attention and emotion.
url: https://niyora.com/research/papers/altered-resting-state-functional-networks-in-patients-with-premenstrual-syndrome-2022/
---

- [Niyora](https://niyora.com/)
- [Research](https://niyora.com/research/)
- [Library](https://niyora.com/research/library/)
- Are brain network connections different in women with PMS?

Case-control study, 2022

# Are brain network connections different in women with PMS?

Yes. Women with PMS showed different brain network organization than healthy women, with changes in areas involved in attention and emotion.

 Early or limited evidence

20 women with PMS and 21 healthy controls

## What they did

Case-control brain imaging study. 20 women with PMS and 21 healthy controls had MRI scans. Graph theory analysis examined how different brain regions connected with each other.

## What they found

Women with PMS had lower small-worldness values (a measure of network efficiency) than healthy controls. Brain changes were mainly in the posterior cingulate cortex, precuneus, and angular gyrus. Abnormal connections involved the thalamus, putamen, and middle cingulate cortex. In the PMS group, symptom severity scores were negatively correlated with local efficiency in the posterior cingulate cortex.

## What it means for you

The study shows that brain networks are organized differently in PMS. This could help scientists understand PMS. The study was small and used expensive brain imaging, so results need confirmation.

20

women with PMS

21

healthy controls

## About the study

Original title Altered resting-state functional networks in patients with premenstrual syndrome: a graph-theoretical based study Authors Liu C, Xuan C, Wu J et al. Journal Brain imaging and behavior Year 2022 Study design Case-control study Participants 20 What was tested Brain imaging analysis comparing network organization between PMS patients and controls Read the paper [doi.org/10.1007/s11682-021-00518-4](https://doi.org/10.1007/s11682-021-00518-4)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

Ask AI about this page

Copy prompt

ChatGPT

↗

Claude

↗

Perplexity

↗

Google AI Mode

↗

Grok

↗