---
title: How does Jingqianshu Granules help PMDD? | Niyora
description: This laboratory and animal study shows the medicine may work through changes in brain chemicals and reduction of brain inflammation. Results cannot yet be con
url: https://niyora.com/research/papers/an-integrated-pharmacochemical-analysis-and-investigation-of-the-effects-of-2025/
---

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- How does Jingqianshu Granules help PMDD?

Lab study, 2025

# How does Jingqianshu Granules help PMDD?

This laboratory and animal study shows the medicine may work through changes in brain chemicals and reduction of brain inflammation. Results cannot yet be confirmed in women with PMDD.

 Early or limited evidence

Animal models in laboratory study

## What they did

Researchers identified the chemical components of Jingqianshu Granules and tested its effects using laboratory and animal models. They measured levels of brain chemicals involved in mood and stress, measured the expression of specific receptor types in a particular brain region, and measured inflammation markers.

## What they found

The medicine improved depression-like behavior, increased levels of two mood-related brain chemicals (allopregnanolone and serotonin), changed the pattern of brain receptors in the region studied, and reduced inflammation markers. Researchers identified 514 chemical components within the medicine, of which 20 were found in the blood after treatment, with 50% coming from two principal ingredients.

## What it means for you

The medicine may work by changing brain chemicals and reducing inflammation in a specific brain region. However, these are findings from animal studies, not from women with PMDD. Human studies are needed to confirm the medicine helps women with PMDD.

514

chemical components identified

20

components found in blood

50%

from principal ingredients

## About the study

Original title An integrated pharmacochemical analysis and investigation of the effects of Jingqianshu granules on premenstrual dysphoric disorder (PMDD) Authors Cheng M, Jiang Z, Yang J et al. Journal Journal of ethnopharmacology Year 2025 Study design Lab study What was tested Jingqianshu Granules Read the paper [doi.org/10.1016/j.jep.2025.120242](https://doi.org/10.1016/j.jep.2025.120242)

## Topics

[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/)[Neurosteroids (allopregnanolone)](https://niyora.com/research/topics/treatment-neurosteroids/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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