---
title: Does ulipristal acetate, a fibroid medication, help PMS symptoms?
description: Possibly yes. 80% of women taking this medication reported improvement in PMS symptoms, though this study had no control group.
url: https://niyora.com/research/papers/an-observation-study-of-the-clinical-evaluation-of-symptom-relief-and-side-2017/
---

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- Does ulipristal acetate, a fibroid medication, help PMS symptoms?

Survey study, 2017

# Does ulipristal acetate, a fibroid medication, help PMS symptoms?

Possibly yes. 80% of women taking this medication reported improvement in PMS symptoms, though this study had no control group.

 Early or limited evidence

80 women with uterine fibroids

## What they did

80 women with uterine fibroids took ulipristal acetate and reported on their bleeding, period pain, side effects, and PMS changes on a questionnaire.

## What they found

67 women (84%) showed improvement in bleeding. 54 women (67%) stopped menstruating. 58 women (70%) reported reduced pain. 80% reported improvement in PMS symptoms. Most women had no or infrequent side effects.

## What it means for you

This progesterone-based medication helps fibroids and may also help PMS, but this is observational data without a comparison group. More controlled research is needed to be sure.

80

women studied

80%

improved PMS symptoms

84%

improved bleeding

## About the study

Original title An observation study of the clinical evaluation of symptom relief and side effects associated with taking ulipristal acetate (esmya) including its effect on pre-menstrual syndrome Authors Chen BF, Powell MC, O'Beirne C Journal Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology Year 2017 Study design Survey study Participants 80 What was tested Ulipristal acetate, a progesterone receptor modulator Read the paper [doi.org/10.1080/01443615.2017.1287687](https://doi.org/10.1080/01443615.2017.1287687)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Dysmenorrhea and period pain](https://niyora.com/research/topics/condition-dysmenorrhea/)[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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