---
title: Which antidepressants are most effective for premenstrual dysphoric disorder?
description: Selective antidepressants that work on serotonin are consistently the most effective. Most studies used daily treatment, but intermittent dosing needs more re
url: https://niyora.com/research/papers/antidepressants-in-the-treatment-of-premenstrual-dysphoric-disorder-1997/
---

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- Which antidepressants are most effective for premenstrual dysphoric disorder?

Review, 1997

# Which antidepressants are most effective for premenstrual dysphoric disorder?

Selective antidepressants that work on serotonin are consistently the most effective. Most studies used daily treatment, but intermittent dosing needs more research.

 Moderate study design

Women with premenstrual dysphoric disorder

## What they did

Literature review of antidepressant treatment research for premenstrual dysphoria over several decades.

## What they found

Selective antidepressants, particularly those active at serotonin receptors, showed the most consistent positive results. PMDD is diagnosed by at least five symptoms including at least one mood symptom, with impairment prospectively confirmed.

## What it means for you

Serotonin-based antidepressants are the main proven treatment for PMDD. The main limitation is that most studies used daily dosing, so intermittent dosing needs more research.

5

Minimum symptoms for PMDD diagnosis

## About the study

Original title Antidepressants in the treatment of premenstrual dysphoric disorder Authors Yonkers KA Journal The Journal of clinical psychiatry Year 1997 Study design Review What was tested Selective antidepressants active at serotonin receptors Read the paper [https://pubmed.ncbi.nlm.nih.gov/9418742/](https://pubmed.ncbi.nlm.nih.gov/9418742/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Anxiolytics and other psychotropics](https://niyora.com/research/topics/treatment-anxiolytics/)[Major depressive disorder](https://niyora.com/research/topics/comorbidity-major-depression/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Randomised trial, 2004

What medications work for PMDD when taken only during the second half of the menstrual cycle?

Survey study, 2001

How common is premenstrual dysphoric disorder and how is it related to other psychiatric conditions?

Survey study, 1997

How are anxiety symptoms and anxiety disorders linked to PMDD?

Review, 2024

What are the most effective treatments for PMDD?

Review, 2015

What treatments work best for PMDD and PMS?

Randomised trial, 2004

Does dosing sertraline continuously or just before the period work better for severe PMS?

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