---
title: Can GnRH agonists plus hormone replacement help severe PMS? | Niyora
description: Evidence suggests that GnRH agonists combined with estrogen-progestin replacement can substantially reduce severe PMS symptoms, particularly in women who do n
url: https://niyora.com/research/papers/applications-of-gonadotropin-releasing-hormone-analogues-in-the-treatment-of-1993/
---

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- Can GnRH agonists plus hormone replacement help severe PMS?

Review, 1993

# Can GnRH agonists plus hormone replacement help severe PMS?

Evidence suggests that GnRH agonists combined with estrogen-progestin replacement can substantially reduce severe PMS symptoms, particularly in women who do not respond to fluoxetine or alprazolam.

 Moderate study design

Literature review (not a study of specific individuals)

## What they did

Review of research on GnRH agonist treatment for PMS, examining how these drugs work and the evidence for their use combined with hormone replacement.

## What they found

GnRH agonists reduce progesterone levels which may be central to PMS development. When combined with estrogen-progestin replacement, they appear to substantially improve PMS symptoms while protecting against the side effects of low estrogen.

## What it means for you

This approach may work well for severe PMS but has not been directly compared to other treatments in controlled trials. An accurate diagnosis must be made first, and doctors should consider fluoxetine and alprazolam before using this approach.

## About the study

Original title Applications of gonadotropin-releasing hormone analogues in the treatment of premenstrual syndrome Authors Mortola JF Journal Clinical obstetrics and gynecology Year 1993 Study design Review What was tested GnRH agonists with estrogen and progestin replacement Read the paper [doi.org/10.1097/00003081-199309000-00032](https://doi.org/10.1097/00003081-199309000-00032)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)[Anxiolytics and other psychotropics](https://niyora.com/research/topics/treatment-anxiolytics/)

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## Related studies

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What treatments work for premenstrual syndrome?

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What treatments work for premenstrual disorders?

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What role do hormones play in PMS and how should we treat it?

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What treatments work for PMDD?

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