--- title: Are low vitamin D levels or certain dairy-related genes linked to premenstrual symptoms? description: Some women with low vitamin D are more likely to experience clumsiness and confusion before their period. A genetic variation affecting how your body digests url: https://niyora.com/research/papers/association-between-lct-13910-c-t-genotype-and-plasma-25hydroxyvitamin-d-with-2016/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Are low vitamin D levels or certain dairy-related genes linked to premenstrual symptoms? Survey study, 2016 # Are low vitamin D levels or certain dairy-related genes linked to premenstrual symptoms? Some women with low vitamin D are more likely to experience clumsiness and confusion before their period. A genetic variation affecting how your body digests dairy is also linked to more clumsiness but fewer cramps. Early or limited evidence 964 women aged 20-29 in Toronto, Canada ## What they did Researchers studied 964 women aged 20-29 in Toronto. They took blood samples to measure vitamin D levels and tested DNA for a gene variant (LCT) related to lactose intolerance. Women answered questions about their premenstrual symptoms. ## What they found Women with deficient vitamin D were 2.63 times more likely to experience clumsiness and 2.57 times more likely to experience confusion compared to women with adequate vitamin D. Women with insufficient vitamin D were 1.82 times more likely to experience confusion. Women with a certain LCT gene variant (CC) were 2.12 times more likely to have clumsiness but about half as likely to have cramps. Vitamin D was not linked to acne, bloating, mood swings, fatigue, headache, anxiety, insomnia, nausea, depression, increased appetite, changes in sexual desire, or wanting to be alone. ## What it means for you Low vitamin D may contribute to clumsiness and confusion as part of PMS, and genes affecting how you digest dairy may also matter. However, this was an observational study, so we cannot know if low vitamin D causes these symptoms or if other factors link them together. 964 women studied, aged 20-29 in Toronto 2.63 times more likely to have clumsiness with low vitamin D 2.57 times more likely to have confusion with low vitamin D ## About the study Original title Association Between LCT ‐13910 C>T Genotype and Plasma 25‐Hydroxyvitamin D with Premenstrual Symptoms Authors Alicia Caroline Jarosz, Ohood Alharbi, Ahmed El‐Sohemy Journal The FASEB Journal Year 2016 Study design Survey study Participants 964 Read the paper [doi.org/10.1096/fasebj.30.1_supplement.127.8](https://doi.org/10.1096/fasebj.30.1_supplement.127.8) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Bloating, breast tenderness and physical symptoms](https://niyora.com/research/topics/symptom-physical-symptoms/)[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Vitamin D](https://niyora.com/research/topics/treatment-vitamin-d/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Survey study, 2019 Does low vitamin D make premenstrual symptoms worse? Systematic review, 2026 Does vitamin D supplementation help PMS symptoms? Randomised trial, 2025 Do vitamin D and E supplements reduce menstrual pain and PMS symptoms? Randomised trial, 2024 Does estetrol/drospirenone birth control improve PMS symptoms? Randomised trial, 2023 Does zinc supplementation reduce PMS symptoms in women? Systematic review, 2021 Does damask rose help reduce menstrual pain, headache, fatigue, anxiety, and bloating? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗