---
title: Are PMS symptoms linked to genetic factors for psychiatric disorders?
description: Yes. Women with PMS were more likely to have genetic factors for depression, bipolar disorder, ADHD, schizophrenia, and autism spectrum disorder. This was a l
url: https://niyora.com/research/papers/associations-between-symptoms-of-premenstrual-disorders-and-polygenic-liability-2023/
---

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- Are PMS symptoms linked to genetic factors for psychiatric disorders?

Cohort study, 2023

# Are PMS symptoms linked to genetic factors for psychiatric disorders?

Yes. Women with PMS were more likely to have genetic factors for depression, bipolar disorder, ADHD, schizophrenia, and autism spectrum disorder. This was a large, well-designed study, so we can be confident in these findings.

 Strong study design

56,725 Norwegian women, average age 29 years

## What they did

Researchers examined 56,725 Norwegian women to see if genetic risk factors (measured using genetic scores) for major psychiatric disorders were linked to PMS symptoms. They assessed PMS during pregnancy using self-reported depression and irritability before menstruation.

## What they found

About 22% of women had PMS symptoms. Women with PMS carried genetic risk factors for major depression, bipolar disorder, ADHD, schizophrenia, and autism spectrum disorder. This connection held true even for women who had never been diagnosed with a psychiatric condition.

## What it means for you

PMS and major psychiatric disorders share genetic roots, which helps explain why some women with PMS are more prone to mood problems. The findings are reliable because of the large sample size, but the study was done in Norway, so results may differ in other populations.

56,725

women studied

21.7%

had PMS symptoms

5

psychiatric disorders linked to PMS

## About the study

Original title Associations Between Symptoms of Premenstrual Disorders and Polygenic Liability for Major Psychiatric Disorders Authors Jaholkowski P, Shadrin AA, Jangmo A et al. Journal JAMA psychiatry Year 2023 Study design Cohort study Participants 56,725 What was tested None Open access Yes Read the paper [doi.org/10.1001/jamapsychiatry.2023.1137](https://doi.org/10.1001/jamapsychiatry.2023.1137)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Cognition, concentration and memory](https://niyora.com/research/topics/symptom-cognition/)[ADHD](https://niyora.com/research/topics/comorbidity-adhd/)[Autism](https://niyora.com/research/topics/comorbidity-autism/)[Bipolar disorder](https://niyora.com/research/topics/comorbidity-bipolar/)[Major depressive disorder](https://niyora.com/research/topics/comorbidity-major-depression/)[Schizophrenia and psychosis](https://niyora.com/research/topics/comorbidity-psychosis/)

Research tells you what helps on average. Niyora helps on the day it hits.

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