---
title: Does estrogen therapy change hormones that affect fluid retention in women with PMS?
description: When women take birth control pills, certain hormones increase, but this change does not happen in women taking hormone replacement or women with PMS. These h
url: https://niyora.com/research/papers/atrial-natriuretic-peptide-plasma-renin-activity-and-aldosterone-in-women-on-1988/
---

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- Does estrogen therapy change hormones that affect fluid retention in women with PMS?

Study, 1988

# Does estrogen therapy change hormones that affect fluid retention in women with PMS?

When women take birth control pills, certain hormones increase, but this change does not happen in women taking hormone replacement or women with PMS. These hormones probably do not directly cause PMS.

 Early or limited evidence

Premenopausal women, postmenopausal women, and women with PMS experiencing fluid retention

## What they did

Researchers measured three hormones in different groups of women: those in the early part of their cycle, women on birth control pills, postmenopausal women with and without hormone replacement, and women with PMS who experience fluid retention.

## What they found

In women on birth control pills, two hormones (ANP and plasma renin activity) were higher, while aldosterone stayed the same. In women on hormone replacement or with PMS, the hormone levels showed no differences. The researchers concluded these hormones change with estrogen or progesterone therapy but probably do not directly cause PMS.

## What it means for you

Even though these hormones change with birth control, they may not explain why women get PMS. This suggests something else causes PMS. The study looked at different groups but did not measure if other things changed.

## About the study

Original title Atrial natriuretic peptide, plasma renin activity, and aldosterone in women on estrogen therapy and with premenstrual syndrome Authors Davidson BJ, Rea CD, Valenzuela GJ Journal Fertility and sterility Year 1988 Study design Study What was tested Observation of women on estrogen or progesterone therapy or with PMS Open access Yes Read the paper [doi.org/10.1016/s0015-0282(16)60308-4](https://doi.org/10.1016/s0015-0282(16)60308-4)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Oral contraceptives and drospirenone](https://niyora.com/research/topics/treatment-hormonal-contraceptives/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/)[Perimenopause and menopause](https://niyora.com/research/topics/comorbidity-perimenopause/)

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