---
title: Does stopping the menstrual cycle help skin conditions that get worse before periods?
description: Yes. In this one woman, both a hormone medicine and surgery to remove her ovaries showed dramatic improvement in her skin condition.
url: https://niyora.com/research/papers/benign-familial-pemphigus-premenstrual-exacerbation-suppressed-by-goserelin-and-1995/
---

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- Does stopping the menstrual cycle help skin conditions that get worse before periods?

Case report, 1995

# Does stopping the menstrual cycle help skin conditions that get worse before periods?

Yes. In this one woman, both a hormone medicine and surgery to remove her ovaries showed dramatic improvement in her skin condition.

 Early or limited evidence

One woman with benign familial pemphigus that worsens before periods

## What they did

Case report of a woman with benign familial pemphigus (a genetic skin condition) that got worse before her period. She was first treated with goserelin, a hormone medicine injected under the skin. Later she had surgery to remove her uterus and ovaries, and was given oestrogen replacement therapy.

## What they found

Her skin condition showed dramatic improvement with the goserelin treatment. The improvement continued and was sustained after the surgery with oestrogen replacement.

## What it means for you

Stopping hormonal changes of the menstrual cycle can improve this skin condition. This is one person's experience, so we do not know if it works for other people.

## About the study

Original title Benign familial pemphigus--premenstrual exacerbation suppressed by goserelin and oophorectomy Authors James MP, Williams RM Journal Clinical and experimental dermatology Year 1995 Study design Case report What was tested Subcutaneous goserelin followed by hysterectomy, bilateral salpingo-oophorectomy, and oestrogen replacement therapy Read the paper [doi.org/10.1111/j.1365-2230.1995.tb01284.x](https://doi.org/10.1111/j.1365-2230.1995.tb01284.x)

## Topics

[Premenstrual exacerbation (PME)](https://niyora.com/research/topics/condition-pme/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)[Surgical menopause](https://niyora.com/research/topics/treatment-surgery/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

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Randomised trial, 2012

Do hysterectomy or hormonal IUDs reduce premenstrual symptoms in women with heavy periods?

Survey study, 2011

Is premenstrual syndrome related to major depression?

Systematic review, 2007

What treatments work for premenstrual syndrome?

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