---
title: Does caffeine improve cognitive function in women with PMS? | Niyora
description: No. Caffeine did not improve attention or working memory in women with PMS after they stopped consuming caffeine, regardless of how quickly they metabolize ca
url: https://niyora.com/research/papers/caffeine-intervention-after-abstinence-does-not-alter-cognitive-parameters-in-2024/
---

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- Does caffeine improve cognitive function in women with PMS?

Non-randomised trial, 2024

# Does caffeine improve cognitive function in women with PMS?

No. Caffeine did not improve attention or working memory in women with PMS after they stopped consuming caffeine, regardless of how quickly they metabolize caffeine.

 Early or limited evidence

26 women of childbearing age with PMS

## What they did

Crossover study with 26 women of childbearing age with PMS who had abstained from caffeine. Participants completed cognitive tests measuring attention and working memory after taking either caffeine or a placebo. Participants were grouped by genetic variation affecting caffeine metabolism (17 fast-metabolizer type and 9 slower-metabolizer types).

## What they found

Both attention and working memory improved after both caffeine and placebo, but there was no statistical difference between the two. Working memory improved for participants with the slower-metabolizer genotype after placebo but not after caffeine. The fast-metabolizer group showed no significant changes with either placebo or caffeine.

## What it means for you

Caffeine does not appear to help cognitive function in women with PMS who have stopped using it. How quickly or slowly a woman metabolizes caffeine did not change this result. However, the study was very small with only 26 participants and only measured short-term effects, so more research is needed.

26

women with PMS in study

17

fast caffeine metabolizer genotype

9

slow caffeine metabolizer genotype

## About the study

Original title Caffeine intervention after abstinence does not alter cognitive parameters in premenstrual syndrome women regardless of CYP1A2 genotype Authors Renata Lira de Assis, Caroline Severo de Assis, Tainá Gomes Diniz et al. Journal Journal of Functional Foods Year 2024 Study design Non-randomised trial Participants 26 What was tested Single dose of caffeine or placebo after caffeine abstinence period Open access Yes Read the paper [doi.org/10.1016/j.jff.2024.106101](https://doi.org/10.1016/j.jff.2024.106101)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Cognition, concentration and memory](https://niyora.com/research/topics/symptom-cognition/)[Diet and nutrition](https://niyora.com/research/topics/treatment-diet/)

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