---
title: Is a certain brain chemical different in women with PMS? | Niyora
description: No. The brain chemical calcitonin gene-related peptide did not show a clear difference in women with PMS compared to women without PMS, and it did not change
url: https://niyora.com/research/papers/calcitonin-gene-related-peptide-the-menstrual-cycle-and-premenstrual-syndrome-1992/
---

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- Is a certain brain chemical different in women with PMS?

Study, 1992

# Is a certain brain chemical different in women with PMS?

No. The brain chemical calcitonin gene-related peptide did not show a clear difference in women with PMS compared to women without PMS, and it did not change noticeably across the menstrual cycle.

 Early or limited evidence

8 women with PMS and 8 control women

## What they did

Blood levels of calcitonin gene-related peptide were measured in 8 women with PMS and 8 women without PMS at four different times during the menstrual cycle.

## What they found

Calcitonin gene-related peptide levels did not show clear fluctuations across the menstrual cycle. There were no clear differences in levels between women with PMS and the control group.

## What it means for you

This particular brain chemical does not seem to explain PMS. However, this is a very small study, so larger studies would be needed to be more confident in this finding.

8

women with PMS

8

control women

4

menstrual cycle phases measured

## About the study

Original title Calcitonin gene-related peptide, the menstrual cycle and premenstrual syndrome Authors van Leeuwen JS, Koppeschaar HP, Kop WJ et al. Journal Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Year 1992 Study design Study What was tested None - observational study Read the paper [doi.org/10.3109/09513599209015555](https://doi.org/10.3109/09513599209015555)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)

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