---
title: Does calcium metabolism work differently in women with PMS? | Niyora
description: Yes. Women with PMS have higher parathyroid hormone (PTH) at midcycle compared to healthy women, suggesting a calcium regulation problem. The study was very s
url: https://niyora.com/research/papers/calcium-regulating-hormones-across-the-menstrual-cycle-evidence-of-a-secondary-1995/
---

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- Does calcium metabolism work differently in women with PMS?

Cohort study, 1995

# Does calcium metabolism work differently in women with PMS?

Yes. Women with PMS have higher parathyroid hormone (PTH) at midcycle compared to healthy women, suggesting a calcium regulation problem. The study was very small.

 Early or limited evidence

12 women (7 with PMS and 5 healthy controls)

## What they did

Measured blood calcium and related hormones at 6 points across one menstrual cycle in 12 women: 7 with PMS and 5 healthy controls.

## What they found

In women with PMS, PTH rose about 30% at midcycle compared to early cycle (49 versus 37 ng/L). Midcycle PTH in PMS women was much higher than in controls (49 versus 26 ng/L). Both groups had lower calcium at midcycle. One woman with PMS took calcium and vitamin D for 3 months and her symptoms improved.

## What it means for you

PMS may involve a calcium metabolism problem linked to hormonal changes. However, the study included only 12 women total and only one woman was treated, so the findings need confirmation in larger studies.

12

women studied

49 vs 37 ng/L

PTH rise in PMS women at midcycle

49 vs 26 ng/L

PTH in PMS versus control women at midcycle

## About the study

Original title Calcium-regulating hormones across the menstrual cycle: evidence of a secondary hyperparathyroidism in women with PMS Authors Thys-Jacobs S, Alvir MJ Journal The Journal of clinical endocrinology and metabolism Year 1995 Study design Cohort study What was tested One woman with PMS received oral calcium and vitamin D daily for 3 months Read the paper [doi.org/10.1210/jcem.80.7.7608284](https://doi.org/10.1210/jcem.80.7.7608284)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Cognition, concentration and memory](https://niyora.com/research/topics/symptom-cognition/)[Calcium](https://niyora.com/research/topics/treatment-calcium/)[Vitamin D](https://niyora.com/research/topics/treatment-vitamin-d/)[Perimenopause and menopause](https://niyora.com/research/topics/comorbidity-perimenopause/)[Thyroid disorders](https://niyora.com/research/topics/comorbidity-thyroid/)

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