---
title: How can animal models help us understand and treat PMDD? | Niyora
description: This review discusses how animal models are used to study PMDD. It concludes that PMDD is complex and involves multiple hormone systems, and effective animal
url: https://niyora.com/research/papers/can-animal-models-resemble-a-premenstrual-dysphoric-condition-2022/
---

- [Niyora](https://niyora.com/)
- [Research](https://niyora.com/research/)
- [Library](https://niyora.com/research/library/)
- How can animal models help us understand and treat PMDD?

Survey study, 2022

# How can animal models help us understand and treat PMDD?

This review discusses how animal models are used to study PMDD. It concludes that PMDD is complex and involves multiple hormone systems, and effective animal models must capture this complexity to develop new treatments.

 Moderate study design

Not applicable - this is a review of animal models and hormone systems

## What they did

This was a review analyzing current knowledge about premenstrual disorders, the hormone systems involved (particularly those controlling the ovaries and stress responses), and the animal models used in PMDD research.

## What they found

The review found that ovarian hormones play a role in PMDD, and several points in how these hormones are made, broken down, and affect the brain could be abnormal in PMDD. The review discusses various animal models used to study PMDD and identifies gaps in how well they represent human PMDD.

## What it means for you

Understanding PMDD requires studying hormone systems in animal models. Because PMDD in humans involves many factors working together, animal models need to be sophisticated to accurately represent the condition and lead to useful treatments.

~80%

women worldwide with mild premenstrual disorders

3-8%

women with severe PMDD

## About the study

Original title Can animal models resemble a premenstrual dysphoric condition? Authors Erika EC, López-Rubalcava C Journal Frontiers in neuroendocrinology Year 2022 Study design Survey study What was tested Not applicable - review article Read the paper [doi.org/10.1016/j.yfrne.2022.101007](https://doi.org/10.1016/j.yfrne.2022.101007)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Neurosteroids (allopregnanolone)](https://niyora.com/research/topics/treatment-neurosteroids/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Systematic review, 2026

Why do some women experience mood changes linked to their menstrual cycle?

Case-control study, 2024

Do steroid hormone levels change differently across the menstrual cycle in women with PMDD?

Survey study, 2022

What causes PMS and PMDD and what new treatments are being studied?

Systematic review, 2021

Are there hormone changes that could explain PMDD or depression in women?

Review, 2017

What causes PMDD and what are the best treatments?

Review, 2003

How do menstrual cycle hormones affect the brain and cause mood disorders like PMDD?

Ask AI about this page

Copy prompt

ChatGPT

↗

Claude

↗

Perplexity

↗

Google AI Mode

↗

Grok

↗