---
title: Are progesterone and its related hormones different in women with PMS?
description: No. Hormone levels were the same in women with PMS and healthy women. Symptom severity did not depend on these hormone levels.
url: https://niyora.com/research/papers/circulating-levels-of-anxiolytic-steroids-in-the-luteal-phase-in-women-with-1994/
---

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- Are progesterone and its related hormones different in women with PMS?

Non-randomised trial, 1994

# Are progesterone and its related hormones different in women with PMS?

No. Hormone levels were the same in women with PMS and healthy women. Symptom severity did not depend on these hormone levels.

 Early or limited evidence

15 women with PMS and 12 healthy women

## What they did

Blood was drawn once during the late luteal phase from 15 women with PMS and 12 healthy control women. Three related hormones (allopregnanolone, pregnanolone, and progesterone) were measured and compared.

## What they found

Allopregnanolone, pregnanolone, and progesterone levels did not differ significantly between women with PMS and controls. How severe women's mood and behavioral symptoms were did not depend on these hormone levels.

## What it means for you

PMS symptoms are probably not caused by too little progesterone or its related hormones. The main limit is that blood was drawn at only one time point and the sample was small.

15

women with PMS

12

healthy women

## About the study

Original title Circulating levels of anxiolytic steroids in the luteal phase in women with premenstrual syndrome and in control subjects Authors Schmidt PJ, Purdy RH, Moore PH Jr et al. Journal The Journal of clinical endocrinology and metabolism Year 1994 Study design Non-randomised trial Participants 15 What was tested None. Hormone levels were measured. Read the paper [doi.org/10.1210/jcem.79.5.7962316](https://doi.org/10.1210/jcem.79.5.7962316)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Neurosteroids (allopregnanolone)](https://niyora.com/research/topics/treatment-neurosteroids/)[Pregnancy and postpartum](https://niyora.com/research/topics/comorbidity-postpartum/)

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