---
title: Can contraceptive medications help people with both bipolar disorder and PMDD?
description: Three people with both conditions improved significantly. These are only three cases, so we need larger studies to be sure.
url: https://niyora.com/research/papers/comorbid-bipolar-disorder-and-premenstrual-dysphoric-disorder-real-patients-2013/
---

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- Can contraceptive medications help people with both bipolar disorder and PMDD?

Case report, 2013

# Can contraceptive medications help people with both bipolar disorder and PMDD?

Three people with both conditions improved significantly. These are only three cases, so we need larger studies to be sure.

 Early or limited evidence

Three people with bipolar disorder and PMDD

## What they did

Doctors reported on three people with bipolar disorder who also had PMDD. They treated them with additional contraceptive medications alongside mood stabilizers.

## What they found

All three responded well to the treatment. Their severe premenstrual symptoms improved significantly.

## What it means for you

These are only three people's experiences. The cases suggest that adding contraceptive medications and mood stabilizers might help people with both conditions, but we need larger, controlled studies to be sure.

three

number of people studied

## About the study

Original title Comorbid bipolar disorder and premenstrual dysphoric disorder: real patients, unanswered questions Authors Frey BN, Minuzzi L Journal Archives of women's mental health Year 2013 Study design Case report What was tested Contraceptive medications and mood stabilizers Read the paper [doi.org/10.1007/s00737-012-0313-z](https://doi.org/10.1007/s00737-012-0313-z)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Bipolar disorder](https://niyora.com/research/topics/comorbidity-bipolar/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Systematic review, 2026

How often do mood disorders and PMS or PMDD occur together?

Cohort study, 2023

Is PMDD a valid medical diagnosis?

Systematic review, 2012

Do women with both bipolar disorder and PMS or PMDD need different treatment?

Study, 2026

How often do people have both PMDD and bipolar disorder together, and how do they affect each other?

Study, 2026

Do anxiety and depression get worse before your period if you already have a mental health condition?

Survey study, 2026

What is the true rate of PMDD, and does it worsen mental health conditions?

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