--- title: How often do people have both PMDD and bipolar disorder together, and how do they affect each other? description: PMDD and bipolar disorder frequently occur together, making mood episodes more frequent and severe. The connection appears to involve hormonal changes in estr url: https://niyora.com/research/papers/comorbidity-of-premenstrual-dysphoric-disorder-and-bipolar-disorder-2026/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - How often do people have both PMDD and bipolar disorder together, and how do they affect each other? Study, 2026 # How often do people have both PMDD and bipolar disorder together, and how do they affect each other? PMDD and bipolar disorder frequently occur together, making mood episodes more frequent and severe. The connection appears to involve hormonal changes in estrogen and progesterone, though how well treatments work remains unclear. Moderate study design Review of research studies on people with both premenstrual dysphoric disorder and bipolar disorder ## What they did Researchers searched medical literature databases (PubMed and Embase) up to June 2025 for studies on PMDD and bipolar disorder occurring together. They found and reviewed 18 papers - 13 original research studies and 5 clinical case reports. ## What they found PMDD and bipolar disorder frequently occurred together. When both were present, mood episodes happened more often and were more intense. The connections appeared to involve multiple factors, particularly hormonal changes in estrogen and progesterone. However, the review found that how well medicines, hormonal treatments, and therapy work for people with both conditions remains little studied. ## What it means for you PMDD and bipolar disorder together are common, but treatment approaches are not well studied. The hormones that drive PMS symptoms also appear to affect bipolar episodes. Care needs to address both hormonal cycles and mood. The main limitation is that the studies reviewed were varied, and treatment effectiveness has not been well studied. 18 articles reviewed 13 original studies 5 case reports ## About the study Original title [Comorbidity of premenstrual dysphoric disorder and bipolar disorder: Characteristics and interactions] Authors Mongnet M, Korngold J, Masson M et al. Journal L'Encephale Year 2026 Study design Study Participants 13 What was tested Review of different medicines, hormonal approaches, and therapy (treatment effectiveness not systematically studied) Read the paper [doi.org/10.1016/j.encep.2026.02.022](https://doi.org/10.1016/j.encep.2026.02.022) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Psychotherapy, counselling and education](https://niyora.com/research/topics/treatment-psychotherapy/)[Bipolar disorder](https://niyora.com/research/topics/comorbidity-bipolar/)[Quality of life and daily functioning](https://niyora.com/research/topics/life-area-quality-of-life/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Systematic review, 2026 Do digital tools and apps help reduce PMS and PMDD symptoms? Study, 2026 Do anxiety and depression get worse before your period if you already have a mental health condition? Survey study, 2025 How common is PMDD among female medical students in Vietnam? Survey study, 2026 What attitudes do nursing students have toward premenstrual dysphoric disorder? Survey study, 2025 How much do nursing students know about PMDD and how do they feel about it? Survey study, 2025 How aware are medical students of PMDD, and how common is it among female medical students? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗