---
title: Do antidepressants help with PMDD symptoms? | Niyora
description: Some antidepressants appear to help relieve PMDD symptoms in controlled studies. The evidence comes from reviews of existing research rather than new data.
url: https://niyora.com/research/papers/coping-with-somatic-comorbidities-striving-for-complete-recovery-2002/
---

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- Do antidepressants help with PMDD symptoms?

Review, 2002

# Do antidepressants help with PMDD symptoms?

Some antidepressants appear to help relieve PMDD symptoms in controlled studies. The evidence comes from reviews of existing research rather than new data.

 Early or limited evidence

Review of medical literature (no specific study population)

## What they did

Reviewed medical literature on depression and anxiety with physical symptoms like pain and headaches, including evidence about how different classes of antidepressants work for these conditions.

## What they found

Selective serotonin reuptake inhibitors have been shown to help relieve PMDD symptoms in controlled studies. Tricyclic antidepressants help with other pain conditions including diabetic nerve pain, fibromyalgia, and headache.

## What it means for you

Some antidepressants may help PMDD symptoms, but more controlled studies are needed. This is a review of existing studies rather than new research data.

## About the study

Original title Coping with somatic comorbidities: striving for complete recovery Authors Allgulander C, Kasper S Journal Psychopharmacology bulletin Year 2002 Study design Review What was tested Antidepressants for PMDD and related conditions Read the paper [doi.org/10.64719/pb.6862](https://doi.org/10.64719/pb.6862)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Eating disorders](https://niyora.com/research/topics/comorbidity-eating-disorders/)[Migraine](https://niyora.com/research/topics/comorbidity-migraine/)[Chronic pain and fibromyalgia](https://niyora.com/research/topics/comorbidity-chronic-pain/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Interview study, 1996

Do antidepressants help treat PMDD and similar conditions?

Review, 2000

What conditions beyond depression can antidepressants treat?

Review, 1999

Do SSRI antidepressants work for PMDD?

Cohort study, 2025

Do women with PMS or PMDD report lower quality of life than women without these conditions?

Systematic review, 2008

What treatments work best for PMS and PMDD?

Review, 2004

How should doctors diagnose and treat PMS and PMDD?

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