---
title: Can measuring a protein in blood cells help diagnose PMDD? | Niyora
description: Lower levels of a protein called beta-arrestin1 were found in women with PMDD, and the reduction was correlated with more severe depression symptoms, suggesti
url: https://niyora.com/research/papers/correlation-of-betaarrestin1-levels-in-mononuclear-leukocytes-with-depression-2014/
---

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- Can measuring a protein in blood cells help diagnose PMDD?

Survey study, 2014

# Can measuring a protein in blood cells help diagnose PMDD?

Lower levels of a protein called beta-arrestin1 were found in women with PMDD, and the reduction was correlated with more severe depression symptoms, suggesting this measurement could help diagnose PMDD.

 Early or limited evidence

Non-pregnant women aged 18-42 with PMS or PMDD symptoms, not on antidepressants

## What they did

Non-pregnant women aged 18-42 with PMS or PMDD symptoms at the luteal phase (not taking antidepressants) were studied. Beta-arrestin1 protein in their blood cells was measured and compared with depression severity scores.

## What they found

Women with depression (PMDD) had significantly lower beta-arrestin1 protein levels compared to those without depression. The reduction in beta-arrestin1 was significantly correlated with the severity of depressive symptoms.

## What it means for you

Beta-arrestin1 measurements might be useful as a blood test to help diagnose PMDD and support questionnaire results. The study does not clearly state how many women were included.

18-42

Age range (years)

Luteal phase

Study timing

## About the study

Original title Correlation of beta‐arrestin1 levels in mononuclear leukocytes with depression scores for women with premenstrual dysphoric disorder (1144.2) Authors Tultul Nayyar, Farzana Alam, William D. Richie et al. Journal The FASEB Journal Year 2014 Study design Survey study What was tested None Read the paper [doi.org/10.1096/fasebj.28.1_supplement.1144.2](https://doi.org/10.1096/fasebj.28.1_supplement.1144.2)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)

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