---
title: Are hormone levels different in women with PMS than in women without?
description: Yes. Women with PMS had significantly lower progesterone in the week before their period and higher estradiol in the last four days of the cycle. Aldosterone
url: https://niyora.com/research/papers/correlations-between-progesterone-oestradiol-and-aldosterone-levels-in-the-1981/
---

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- Are hormone levels different in women with PMS than in women without?

Case-control study, 1981

# Are hormone levels different in women with PMS than in women without?

Yes. Women with PMS had significantly lower progesterone in the week before their period and higher estradiol in the last four days of the cycle. Aldosterone levels were the same.

 Early or limited evidence

20 women with PMS and 10 healthy women

## What they did

Measured blood hormone levels in 20 women with PMS and 10 women without PMS at different points in their cycle using a method called radioimmunoassay.

## What they found

Pooled progesterone from days 9 to 5 before the period was significantly lower in PMS women than controls (P less than 0.05). Estradiol was higher in PMS women over the last 4 days of the cycle (P less than 0.01). Aldosterone showed no significant difference.

## What it means for you

Low progesterone and high estradiol may play a role in PMS, but this was a small study from 1981. We cannot be certain that these hormone differences cause PMS symptoms or whether all women with PMS have the same pattern.

20

women with PMS

10

women without PMS

P<0.01

estradiol difference (last 4 days)

## About the study

Original title Correlations between progesterone, oestradiol and aldosterone levels in the premenstrual syndrome Authors Munday MR, Brush MG, Taylor RW Journal Clinical endocrinology Year 1981 Study design Case-control study What was tested None Read the paper [doi.org/10.1111/j.1365-2265.1981.tb00359.x](https://doi.org/10.1111/j.1365-2265.1981.tb00359.x)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)

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