---
title: Does curcumin-piperine combination improve antioxidant activity in women with PMS and period pain?
description: Curcumin significantly increased free-radical scavenging activity in the blood compared to placebo. However, other antioxidant measures showed no difference,
url: https://niyora.com/research/papers/curcuminoid-piperine-combination-improves-radical-scavenging-activity-in-women-2024/
---

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- Does curcumin-piperine combination improve antioxidant activity in women with PMS and period pain?

Randomised trial, 2024

# Does curcumin-piperine combination improve antioxidant activity in women with PMS and period pain?

Curcumin significantly increased free-radical scavenging activity in the blood compared to placebo. However, other antioxidant measures showed no difference, so the practical benefit is unclear.

 Strong study design

80 young girls with PMS and dysmenorrhea

## What they did

Eighty young girls with PMS and dysmenorrhea were randomly given either curcuminoids (500 mg with 5 mg piperine) or placebo daily. The treatment ran from 7 days before menstrual bleeding until 3 days after it started, repeated for 3 successive menstrual cycles.

## What they found

Curcumin treatment significantly increased free-radical scavenging activity of serum compared to placebo (p=0.031). However, no significant differences were found between groups in other antioxidant measures including serum and urinary FRAP, DPPH, and MDA.

## What it means for you

Curcumin may boost the body's antioxidant system during PMS and period pain, though the clinical benefit is unclear since other antioxidant markers did not improve. The study involved only young girls and tested relatively low doses, so larger studies with higher doses are needed.

500 mg

curcuminoids plus 5 mg piperine daily

80

young girls

3

menstrual cycles of treatment

## About the study

Original title Curcuminoid-Piperine Combination Improves Radical Scavenging Activity in Women with Premenstrual Syndrome and Dysmenorrhea: A Post-hoc Analysis of a Randomized Clinical Study Authors Karbasi S, Seyedabadi S, Mozaffari S et al. Journal Chonnam medical journal Year 2024 Study design Randomised trial What was tested Curcuminoids 500 mg with 5 mg piperine daily for 7 days pre- and 3 days post-menstruation for 3 cycles vs placebo Open access Yes Read the paper [doi.org/10.4068/cmj.2024.60.2.113](https://doi.org/10.4068/cmj.2024.60.2.113)

## Topics

[Dysmenorrhea and period pain](https://niyora.com/research/topics/condition-dysmenorrhea/)[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Adolescents and young people](https://niyora.com/research/topics/life-area-adolescents/)[Stress](https://niyora.com/research/topics/symptom-stress/)[Curcumin and turmeric](https://niyora.com/research/topics/treatment-curcumin/)

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## Related studies

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