---
title: Can psychotic symptoms be linked to the menstrual cycle? | Niyora
description: Yes. This girl developed psychotic symptoms that appeared right before her period and disappeared when her period started, suggesting a link to the menstrual
url: https://niyora.com/research/papers/cyclic-psychosis-associated-with-the-menstrual-cycle-1993/
---

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- Can psychotic symptoms be linked to the menstrual cycle?

Case report, 1993

# Can psychotic symptoms be linked to the menstrual cycle?

Yes. This girl developed psychotic symptoms that appeared right before her period and disappeared when her period started, suggesting a link to the menstrual cycle. This is a single case.

 Early or limited evidence

1 girl aged 14 with PMS

## What they did

A 14-year-old girl with PMS who developed psychotic symptoms during two premenstrual periods was treated with dehydroxyprogesterone for two cycles, then placebo for three cycles.

## What they found

Her psychotic symptoms resolved completely when her period started in both cases. The symptoms did not return after the two cycles when she had them. Her PMS also resolved in the next cycle.

## What it means for you

Psychotic symptoms linked to the menstrual cycle might be a rare condition on its own. We cannot know from this single case whether it happens in other people or how common it is.

1

girl studied

14

age in years

2

menstrual cycles with psychotic symptoms

## About the study

Original title Cyclic psychosis associated with the menstrual cycle Authors Stein D, Hanukoglu A, Blank S et al. Journal The British journal of psychiatry : the journal of mental science Year 1993 Study design Case report What was tested Dehydroxyprogesterone for two cycles, then placebo for three cycles Read the paper [doi.org/10.1192/bjp.163.6.824](https://doi.org/10.1192/bjp.163.6.824)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Schizophrenia and psychosis](https://niyora.com/research/topics/comorbidity-psychosis/)

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## Related studies

Review, 2024

What is premenstrual exacerbation and how does it affect different psychiatric illnesses?

Cohort study, 2023

Are PMS symptoms linked to genetic factors for psychiatric disorders?

Systematic review, 2022

Do mental health disorders get worse during the menstrual cycle?

Review, 2002

What treatments work best for PMS and PMDD?

Review, 1989

Are mental health conditions linked to the reproductive cycle?

Study, 2026

Do anxiety and depression get worse before your period if you already have a mental health condition?

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