---
title: Is there something different about calcium and vitamin D levels in women with PMDD?
description: Yes, this study found women with PMDD had some differences in calcium-related hormones across the cycle compared to women without PMDD, including lower vitami
url: https://niyora.com/research/papers/cyclical-changes-in-calcium-metabolism-across-the-menstrual-cycle-in-women-with-2007/
---

- [Niyora](https://niyora.com/)
- [Research](https://niyora.com/research/)
- [Library](https://niyora.com/research/library/)
- Is there something different about calcium and vitamin D levels in women with PMDD?

Cohort study, 2007

# Is there something different about calcium and vitamin D levels in women with PMDD?

Yes, this study found women with PMDD had some differences in calcium-related hormones across the cycle compared to women without PMDD, including lower vitamin D levels in the second half of the cycle, though this does not prove it causes PMDD.

 Early or limited evidence

Women with and without PMDD, tracked across their menstrual cycle.

## What they did

Researchers compared women with and without PMDD. The women tracked their symptoms for 2 months, then had their calcium-related hormones measured across one full menstrual cycle at several time points.

## What they found

Calcium-related hormones changed significantly across the cycle in both groups. Women with PMDD had lower ionized calcium at menses (1.166 vs 1.182 mmol/liter, p=0.027), lower urine calcium at three points in the cycle, and lower active vitamin D (1,25-dihydroxyvitamin D) in the luteal phase, the time before a period (45.0 vs 50.6 pg/ml, p=0.032).

## What it means for you

The drop in active vitamin D before a period may help explain some PMDD symptoms, but this is an early finding from one study comparing two groups, not a treatment trial, so it cannot yet tell women whether taking vitamin D or calcium would help.

1.166 vs 1.182

Ionized calcium at menses, PMDD vs controls (mmol/liter)

45.0 vs 50.6

Active vitamin D in luteal phase, PMDD vs controls (pg/ml)

p=0.032

Statistical significance for vitamin D difference

## About the study

Original title Cyclical changes in calcium metabolism across the menstrual cycle in women with premenstrual dysphoric disorder Authors Thys-Jacobs S, McMahon D, Bilezikian JP Journal The Journal of clinical endocrinology and metabolism Year 2007 Study design Cohort study What was tested No treatment tested; hormone and mineral levels were measured, not changed. Read the paper [doi.org/10.1210/jc.2006-2726](https://doi.org/10.1210/jc.2006-2726)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Calcium](https://niyora.com/research/topics/treatment-calcium/)[Vitamin D](https://niyora.com/research/topics/treatment-vitamin-d/)[Thyroid disorders](https://niyora.com/research/topics/comorbidity-thyroid/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Study, 2008

Does calcium and vitamin D deficiency cause PMS?

Review, 2011

What are PMS and PMDD, and how common are they?

Review, 2016

How common are PMS and PMDD, and what are the best treatments?

Review, 2000

Can calcium and vitamin D help with PMS symptoms?

Study, 2025

Could taking a combination of vitamins and minerals help with PMS and PMDD symptoms?

Randomised trial, 2024

Does what you eat affect PMS symptoms?

Ask AI about this page

Copy prompt

ChatGPT

↗

Claude

↗

Perplexity

↗

Google AI Mode

↗

Grok

↗