---
title: Does danazol help premenstrual syndrome? | Niyora
description: Half of 12 women with severe PMS benefited. However, a second group had a high dropout rate because side effects outweighed any benefits.
url: https://niyora.com/research/papers/danazol-and-the-premenstrual-syndrome-1979/
---

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- Does danazol help premenstrual syndrome?

Non-randomised trial, 1979

# Does danazol help premenstrual syndrome?

Half of 12 women with severe PMS benefited. However, a second group had a high dropout rate because side effects outweighed any benefits.

 Early or limited evidence

12 women with severe premenstrual symptoms plus additional fresh cases

## What they did

Tested danazol at doses of 200-800 mg daily in 12 women with severe PMS and at 400 mg daily in a second group of fresh cases as first or second treatment choice.

## What they found

Of 12 women with severe symptoms, 6 benefited from treatment. The second group had a high dropout rate and benefits were outweighed by side effects.

## What it means for you

Danazol may help severe PMS, especially breast tenderness, but side effects are a major problem. The study was very small with no control group and high dropout in one arm.

12

Women with severe PMS

6

Benefited from danazol (50%)

## About the study

Original title Danazol and the premenstrual syndrome Authors Day J Journal Postgraduate medical journal Year 1979 Study design Non-randomised trial Participants 12 What was tested Danazol 200-800 mg daily (first group), 400 mg daily (second group) Read the paper [https://pubmed.ncbi.nlm.nih.gov/395526/](https://pubmed.ncbi.nlm.nih.gov/395526/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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