---
title: Can a rare brain structure problem cause psychosis-like symptoms?
description: In this one person's case, yes, a brain structure condition called Chiari I malformation appeared to be the cause of repeated psychosis-like episodes and seiz
url: https://niyora.com/research/papers/detection-of-monoamine-transmitters-in-serum-of-macaque-by-high-performance-2007/
---

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- Can a rare brain structure problem cause psychosis-like symptoms?

Study, 2007

# Can a rare brain structure problem cause psychosis-like symptoms?

In this one person's case, yes, a brain structure condition called Chiari I malformation appeared to be the cause of repeated psychosis-like episodes and seizure-like symptoms.

 Early or limited evidence

One adult with Chiari I malformation

## What they did

Doctors described a single clinical case of an adult who had repeated psychotic episodes and seizure-like symptoms. They used detailed brain imaging (MRI) of the brain and the junction between the skull and spine to look for the cause.

## What they found

The brain imaging showed that the person had Chiari I malformation, a structural brain condition, and this was identified as the likely cause of the seizure-like events, neurological signs, and psychosis-like illness.

## What it means for you

This describes only one person, so it cannot show how common this cause is or whether it would apply to anyone else. It is not related to PMS or PMDD and does not involve the menstrual cycle.

## About the study

Original title [Detection of monoamine transmitters in serum of macaque by high performance liquid chromatograghy with electrochemical detector] Authors Li F, Zhang HY Journal Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica Year 2007 Study design Study What was tested None tested; brain imaging (MRI) was used to find the cause Read the paper [https://pubmed.ncbi.nlm.nih.gov/17608225/](https://pubmed.ncbi.nlm.nih.gov/17608225/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)

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