---
title: What is the recommended way to diagnose and treat PMDD? | Niyora
description: PMDD affects 3-5% of women and causes severe symptoms. Selective serotonin reuptake inhibitors (SSRIs, a type of antidepressant) taken during the luteal phase
url: https://niyora.com/research/papers/diagnostic-and-therapeutic-algorithm-for-the-treatment-of-premenstrual-dysphoric-2010/
---

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- What is the recommended way to diagnose and treat PMDD?

Review, 2010

# What is the recommended way to diagnose and treat PMDD?

PMDD affects 3-5% of women and causes severe symptoms. Selective serotonin reuptake inhibitors (SSRIs, a type of antidepressant) taken during the luteal phase (the two weeks before menstruation) are considered first-line therapy.

 Strong study design

Women with PMDD

## What they did

This is a review article presenting a diagnostic algorithm and treatment approach for PMDD.

## What they found

PMDD affects 3-5% of women and causes severe depression and anxiety symptoms that impair social and work functioning. The symptoms are linked to serotonin dysregulation. SSRIs taken only during the symptomatic luteal phase are first-line therapy.

## What it means for you

PMDD has a clear recommended treatment pathway using antidepressants taken intermittently. This is a review, not original research.

3-5%

women with PMDD

## About the study

Original title [Diagnostic and therapeutic algorithm for the treatment of premenstrual dysphoric disorder] Authors Strkalj Ivezić S, Kusan Jukić M, Tikvica A et al. Journal Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti Year 2010 Study design Review What was tested SSRI antidepressants (taken during luteal phase) Read the paper [https://pubmed.ncbi.nlm.nih.gov/20922861/](https://pubmed.ncbi.nlm.nih.gov/20922861/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Systematic review, 2024

What are the best treatments for PMDD and PMS?

Review, 2024

What are the most effective treatments for PMDD?

Systematic review, 2024

Do SSRI antidepressants help treat PMS and PMDD?

Randomised trial, 2023

Does taking sertraline when PMDD symptoms start improve how well women function?

Guideline, 2023

How are GnRH agonists used to treat PMDD that doesn't respond to standard medications?

Review, 2022

What causes severe PMS and what treatments work?

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