---
title: Does creatine supplementation help with exercise and mood during the menstrual cycle?
description: The review suggests creatine may help reduce fatigue during the luteal phase and potentially improve mood during the premenstrual phase, but dedicated randomi
url: https://niyora.com/research/papers/differences-in-response-to-creatine-supplementation-in-women-depending-on-the-2026/
---

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- Does creatine supplementation help with exercise and mood during the menstrual cycle?

Randomised trial, 2026

# Does creatine supplementation help with exercise and mood during the menstrual cycle?

The review suggests creatine may help reduce fatigue during the luteal phase and potentially improve mood during the premenstrual phase, but dedicated randomized controlled trials are still needed to confirm this.

 Early or limited evidence

Narrative review of studies (not a single population studied)

## What they did

Narrative literature review searching PubMed, Scopus, and Google Scholar. Data from meta-analyses, systematic reviews, observational studies, and RCTs on creatine and female physiology were synthesized.

## What they found

Women have lower endogenous creatine stores and different creatine kinetics than men. The luteal phase is associated with increased protein breakdown, reduced exercise tolerance, and impaired recovery. Creatine supplementation reduced the fatigue index during the luteal phase and shows potential for mood improvement during the premenstrual phase.

## What it means for you

This is a review of existing studies, not a new clinical trial, so the evidence is preliminary. The luteal phase may be when women's bodies benefit most from creatine. Proper randomized controlled trials specifically testing creatine in women during the luteal phase are still needed.

lower

endogenous creatine stores in women than men

luteal phase

when fatigue index was reduced

## About the study

Original title Differences in Response to Creatine Supplementation in Women Depending on the Menstrual Cycle Phase: A Narrative Review Authors Wiktoria Myślicka, Valery Veyeunik, Agata Chrobak et al. Journal Quality in Sport Year 2026 Study design Randomised trial What was tested Creatine supplementation timing relative to menstrual cycle phase Open access Yes Read the paper [doi.org/10.12775/qs.2026.62.73295](https://doi.org/10.12775/qs.2026.62.73295)

## Topics

[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Exercise and yoga](https://niyora.com/research/topics/treatment-exercise/)

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