---
title: Does a vitamin and mineral supplement help PMS symptoms? | Niyora
description: Possibly, especially at higher doses. The 12-tablet dose helped all four types of PMS symptoms, and the 6-tablet dose helped three types. However, placebo als
url: https://niyora.com/research/papers/effect-of-a-nutritional-supplement-on-premenstrual-symptomatology-in-women-with-1991/
---

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- Does a vitamin and mineral supplement help PMS symptoms?

Randomised trial, 1991

# Does a vitamin and mineral supplement help PMS symptoms?

Possibly, especially at higher doses. The 12-tablet dose helped all four types of PMS symptoms, and the 6-tablet dose helped three types. However, placebo also had significant effects.

 Moderate study design

44 women with PMS, screened to exclude other physical or psychological conditions

## What they did

A double-blind study of 44 women with PMS, carefully screened to exclude other physical or psychological conditions. Women completed symptom questionnaires for 1 month as baseline, then were randomly assigned to placebo or 6 or 12 tablets daily of the supplement for 3 menstrual cycles. Symptoms were measured in both the follicular and luteal phases of the cycle.

## What they found

All women had significant symptom differences between follicular and luteal phases at baseline. Placebo significantly improved two of four PMS symptom subgroups. The 6-tablet supplement dose significantly improved three subgroups, and the 12-tablet dose significantly improved all four subgroups.

## What it means for you

The higher dose of this supplement may help all PMS symptom types, but placebo effects were also strong, making it unclear how much improvement came from the supplement itself versus expectation. The study was relatively small with 44 women.

44

women studied

3

menstrual cycles of treatment

4

PMS symptom subgroups tested

## About the study

Original title Effect of a nutritional supplement on premenstrual symptomatology in women with premenstrual syndrome: a double-blind longitudinal study Authors London RS, Bradley L, Chiamori NY Journal Journal of the American College of Nutrition Year 1991 Study design Randomised trial Participants 44 What was tested Vitamin and mineral supplement at two doses: 6 or 12 tablets daily Read the paper [doi.org/10.1080/07315724.1991.10718176](https://doi.org/10.1080/07315724.1991.10718176)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Diet and nutrition](https://niyora.com/research/topics/treatment-diet/)

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