--- title: Does combining calcium and vitamin B6 reduce premenstrual syndrome symptoms? description: Yes, combining calcium and vitamin B6 reduced PMS symptoms significantly more than vitamin B6 alone in university students. url: https://niyora.com/research/papers/effect-of-combined-use-of-calcium-and-vitamin-b6-on-premenstrual-syndrome-2016/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does combining calcium and vitamin B6 reduce premenstrual syndrome symptoms? Randomised trial, 2016 # Does combining calcium and vitamin B6 reduce premenstrual syndrome symptoms? Yes, combining calcium and vitamin B6 reduced PMS symptoms significantly more than vitamin B6 alone in university students. Moderate study design 76 university students at Hamadan University of Medical Sciences ## What they did 76 university students were randomly divided into two groups of 38. One group took calcium (500mg) and vitamin B6 (40mg) twice daily for two months. The other group took vitamin B6 only, twice daily for two months. PMS symptoms were measured before and after using depression and daily symptom questionnaires. ## What they found Symptoms decreased in both groups, but the decrease was more significant in the calcium plus vitamin B6 group compared to vitamin B6 alone. ## What it means for you Taking calcium and vitamin B6 together may work better than B6 alone for PMS. Study only included university students, so results may not apply to all women. Duration was short at two months. 76 women studied 500mg daily calcium dose 40mg daily vitamin B6 dose ## About the study Original title Effect of Combined Use of Calcium and Vitamin B6 on Premenstrual Syndrome Symptoms: a Randomized Clinical Trial Authors Masoumi SZ, Ataollahi M, Oshvandi K Journal Journal of caring sciences Year 2016 Study design Randomised trial Participants 76 What was tested Calcium 500mg plus vitamin B6 40mg twice daily for two months Open access Yes Read the paper [doi.org/10.15171/jcs.2016.007](https://doi.org/10.15171/jcs.2016.007) Original abstract Introduction: Premenstrual syndrome is one of the most common disorders in women, which includes a group of psychological and physical symptoms. The aim of this study was to examine the impact of combined use of calcium and vitamin B6 on premenstrual syndrome symptoms. Methods: This double blind randomized controlled was carried out on 76 students of Hamadan University of Medical Sciences. Students were randomly allocated to two groups. (38 people in each group). Student in intervention groups received calcium tablet (500mg) and vitamin B6 (40 mg) and student in intervention groups received only vitamin B6 twice a day for two consecutive months. The symptoms were assessed by Beck depression inventory (BDI) and daily symptom records (DSR) questionnaires. Analyses were carried out by test-retest method, Chi-square, Mann-Whitney, Independent t-test, and paired t-test using SPSS software ver.13. Results The result showed that although the severity of symptoms decreased in both groups, but this reduction was more significant in the combined calcium and vitamin B6 group. Conclusion: According to the result, using of combination of calcium and vitamin B6 leads to better controlling of the premenstrual syndrome symptoms. Therefore it is recommended for women who suffer from these syndromes. Reproduced under CC-BY. ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Calcium](https://niyora.com/research/topics/treatment-calcium/)[Vitamin B6](https://niyora.com/research/topics/treatment-vitamin-b6/)[Students and academic performance](https://niyora.com/research/topics/life-area-education/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Study, 1998 Does diet and supplements help PMS? Cohort study, 2014 Do lifestyle and nutrition affect menstrual symptoms? Survey study, 2011 Do overweight or obese women have worse PMS than normal weight women? Randomised trial, 2026 Does calcium and vitamin D supplementation reduce PMS symptoms? Systematic review, 2025 Do nutritional interventions help with emotional symptoms of PMS? Randomised trial, 2017 Does calcium reduce PMS symptoms? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗