--- title: Do vitamin D and E supplements reduce menstrual pain and PMS symptoms? description: Yes, vitamin D and E supplements significantly reduced menstrual pain and PMS symptoms over 4 months, especially in women with low vitamin D levels. url: https://niyora.com/research/papers/effect-of-vitamin-d-and-e-supplementation-on-pain-relief-and-premenstrual-2025/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Do vitamin D and E supplements reduce menstrual pain and PMS symptoms? Randomised trial, 2025 # Do vitamin D and E supplements reduce menstrual pain and PMS symptoms? Yes, vitamin D and E supplements significantly reduced menstrual pain and PMS symptoms over 4 months, especially in women with low vitamin D levels. Strong study design 106 people with primary dysmenorrhea ## What they did Double-blind randomized controlled trial with 106 people with primary dysmenorrhea (painful menstrual cramps). Half received vitamin D and E supplements and half received placebo for 4 months. Pain intensity and PMS symptoms were measured at the start and after 4 months. ## What they found The supplement group had significantly larger reductions in pain (dropped from 7.85 to 3.75 on a scale, mean difference 4.10, p < 0.001) compared to placebo (dropped from 7.68 to 6.02). PMS symptoms improved significantly in the supplement group (score dropped from 32.42 to 9.02, p < 0.001). Women with higher baseline vitamin D had lower pain. ## What it means for you Vitamin D and E supplements can significantly reduce menstrual pain and PMS symptoms, particularly for women with low vitamin D. This suggests checking vitamin D status and supplementing could help many women. The strength is the double-blind design and large sample. Main limitation: studied dysmenorrhea specifically, so results may differ for PMS without severe pain. 106 Sample size 7.85 to 3.75 Pain reduction 4 months Duration ## About the study Original title Effect of vitamin D and E supplementation on pain relief and premenstrual symptoms in primary dysmenorrhea: a randomized controlled trial Authors Hosseini MS, Talayeh M, Haghbin Toutounchi A et al. Journal BMC women's health Year 2025 Study design Randomised trial Participants 106 What was tested Vitamin D and E supplements for 4 months Open access Yes Read the paper [doi.org/10.1186/s12905-025-04007-4](https://doi.org/10.1186/s12905-025-04007-4) Original abstract Introduction: Primary dysmenorrhea is a common condition characterized by painful menstrual cramps. Vitamin D and E are suggested to have potential benefits in managing dysmenorrhea. This study aimed to investigate the effects of vitamin D and E supplements combination on pain intensity and premenstrual symptoms in individuals with primary dysmenorrhea. Methods: A double blinded randomized controlled trial was conducted with 106 participants diagnosed with primary dysmenorrhea. The participants were randomly assigned to either the intervention group (received vitamin D and E supplements) or the control group (received placebo). Pain intensity and premenstrual symptoms were assessed at baseline and after four months of supplementation. Results: The intervention group exhibited a significant reduction in pain intensity (NPRS: from 7.85 ± 1.15 to 3.75 ± 1.40; mean difference - 4.10, 95% CI: -4.61 to -3.58, p < 0.001) compared to controls (7.68 ± 1.20 to 6.02 ± 1.70). Premenstrual symptoms significantly improved (PMS score: 32.42 ± 4.67 to 9.02 ± 8.84, Δ=-23.40, 95% CI: -26.51 to -21.02, p < 0.001). Baseline vitamin D inversely correlated with pain (r=-0.768, p = 0.001). Conclusion: Combined vitamin D and E supplementation significantly reduces pain and PMS in vitamin D-deficient women. Healthcare providers may consider this regimen for dysmenorrhea management, pending further optimization studies. Trial registration: In IRCT.ir with number IRCT20220720055506N1 at 2023-02-01. Reproduced under CC-BY. ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Dysmenorrhea and period pain](https://niyora.com/research/topics/condition-dysmenorrhea/)[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Vitamin D](https://niyora.com/research/topics/treatment-vitamin-d/)[Vitamin E](https://niyora.com/research/topics/treatment-vitamin-e/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Study, 2024 Does a combination of evening primrose oil, tocotrienol, and vitamin B6 reduce premenstrual symptoms? Randomised trial, 2025 Can soy isoflavone supplements help with PMS and PMDD symptoms? Survey study, 2012 Does vitamin D affect PMS symptoms? Systematic review, 2025 Does digital healthcare help manage period pain and PMS? Cohort study, 2025 How common is PMS in Chinese teenage girls, and what factors are linked to it? Systematic review, 2025 Does teaching adolescent girls about their menstrual cycle and health help reduce period pain and PMS? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗