--- title: Does high-dose vitamin D help PMS symptoms in women with low vitamin D? description: Yes. Vitamin D supplementation significantly improved overall PMS symptoms, especially mood-related symptoms like depression, in women with low vitamin D. url: https://niyora.com/research/papers/effect-of-vitamin-d-supplementation-on-symptoms-severity-in-vitamin-d-2024/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does high-dose vitamin D help PMS symptoms in women with low vitamin D? Randomised trial, 2024 # Does high-dose vitamin D help PMS symptoms in women with low vitamin D? Yes. Vitamin D supplementation significantly improved overall PMS symptoms, especially mood-related symptoms like depression, in women with low vitamin D. Strong study design 44 women with low vitamin D and PMS ## What they did A 4-month randomized double-blind controlled trial with 44 women with low vitamin D and PMS. One group received 50,000 IU of vitamin D every 2 weeks, the other received placebo. Researchers measured vitamin D blood levels and PMS symptoms. ## What they found In the vitamin D group, blood vitamin D rose from 21 plus or minus 8 ng/ml to 40 plus or minus 8 ng/ml. In the placebo group, it rose slightly from 21 plus or minus 7 ng/ml to 23 plus or minus 7 ng/ml. Overall PMS symptoms improved significantly in the vitamin D group (p less than 0.001). Depression symptoms decreased by 53 percent, water retention by 28 percent. Mood symptoms improved more than physical symptoms. ## What it means for you Vitamin D helps PMS, particularly mood symptoms like depression, in women with low vitamin D. The study was small and focused on vitamin D insufficiency, so results apply mainly to women with low levels. 50,000 IU dose of vitamin D given every 2 weeks 53% improvement in depression symptoms p < 0.001 highly significant improvement overall ## About the study Original title Effect of vitamin D supplementation on symptoms severity in vitamin D insufficient women with premenstrual syndrome: A randomized controlled trial Authors Heidari H, Abbasi K, Feizi A et al. Journal Clinical nutrition ESPEN Year 2024 Study design Randomised trial What was tested 50,000 IU vitamin D every 2 weeks for 16 weeks (4 months) Read the paper [doi.org/10.1016/j.clnesp.2023.11.014](https://doi.org/10.1016/j.clnesp.2023.11.014) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Vitamin D](https://niyora.com/research/topics/treatment-vitamin-d/)[Quality of life and daily functioning](https://niyora.com/research/topics/life-area-quality-of-life/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Systematic review, 2025 Do nutritional interventions help with emotional symptoms of PMS? Randomised trial, 2025 How effective are non-hormonal treatments for severe PMS? Survey study, 2025 Can a smartphone app help diagnose and monitor PMS? Survey study, 2025 How much do lifestyle and diet affect PMS symptoms? Study, 2024 How do lifestyle factors like diet, exercise, and stress affect menstrual health and PMS? Review, 2023 Can diet and vitamins help reduce PMS symptoms? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗