--- title: Does calcium and vitamin D supplementation reduce PMS symptoms? description: Yes. Women taking 1,000 mg calcium daily plus 50,000 IU vitamin D every two weeks for 12 weeks showed significantly greater improvements in anger, anxiety, fo url: https://niyora.com/research/papers/effectiveness-of-non-hormonal-treatment-on-moderate-to-severe-premenstrual-2026/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does calcium and vitamin D supplementation reduce PMS symptoms? Randomised trial, 2026 # Does calcium and vitamin D supplementation reduce PMS symptoms? Yes. Women taking 1,000 mg calcium daily plus 50,000 IU vitamin D every two weeks for 12 weeks showed significantly greater improvements in anger, anxiety, food cravings, physical symptoms, and work efficiency compared to placebo. Strong study design 100 university students aged 18 to 40 (mean age 25.7 years) with moderate to severe PMS ## What they did Randomly assigned 100 female university students aged 18 to 40 with moderate to severe PMS to either calcium (1,000 mg daily) plus vitamin D (50,000 IU every two weeks) or placebo for 12 weeks. Symptoms were measured using the Premenstrual Symptoms Screening Tool Adolescent. ## What they found Compared to placebo, the calcium and vitamin D group had significant improvements in anger or irritability (P=0.04), anxiety or tension (P=0.03), reduced interest in work (P=0.001), overeating or food cravings (P<0.001), physical symptoms (P=0.04), and work efficiency (P=0.01). ## What it means for you Calcium and vitamin D supplements may help emotional and physical PMS symptoms and improve work function. However, this study was done in university students in one hospital in Pakistan, so results may differ in other populations or age groups. 100 women studied 1000 mg calcium daily 12 weeks of supplementation ## About the study Original title Effectiveness of Non-Hormonal Treatment on Moderate to Severe Premenstrual Syndrome: A Double Blind Randomized Control Trial Authors Haleema Sadia, Nadia Zahid, Gulfreen Waheed et al. Journal Journal of Bahria University Medical and Dental College Year 2026 Study design Randomised trial Participants 100 What was tested Calcium (1,000 mg daily) plus vitamin D (50,000 IU every 2 weeks) versus placebo for 12 weeks Open access Yes Read the paper [doi.org/10.51985/jbumdc2025721](https://doi.org/10.51985/jbumdc2025721) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Irritability and anger](https://niyora.com/research/topics/symptom-irritability-anger/)[Calcium](https://niyora.com/research/topics/treatment-calcium/)[Vitamin D](https://niyora.com/research/topics/treatment-vitamin-d/)[Students and academic performance](https://niyora.com/research/topics/life-area-education/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Cohort study, 2010 How do anxiety disorders differ across different life stages? Randomised trial, 2009 Is dydrogesterone or calcium plus vitamin D better for severe PMS? Study, 2026 What are premenstrual syndrome and premenstrual dysphoric disorder? Case-control study, 2023 Do women with premenstrual syndrome respond differently to emotional stress? Randomised trial, 2022 Does PMS50 supplementation reduce psychological symptoms of premenstrual syndrome? Randomised trial, 2021 Does hypnotherapy reduce pain and emotional distress in women with PMDD? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗