--- title: Does a Chinese herbal medicine affect abnormal brain receptors in rats with PMS-like symptoms? description: Yes, in rats with PMS-like symptoms, the herb Baixiangdan reduced abnormally high expression of a specific brain receptor involved in mood regulation. url: https://niyora.com/research/papers/effects-of-baixiangdan-capsule-on-location-and-expression-levels-of-gaba-a-2010/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does a Chinese herbal medicine affect abnormal brain receptors in rats with PMS-like symptoms? Randomised trial, 2010 # Does a Chinese herbal medicine affect abnormal brain receptors in rats with PMS-like symptoms? Yes, in rats with PMS-like symptoms, the herb Baixiangdan reduced abnormally high expression of a specific brain receptor involved in mood regulation. Early or limited evidence Laboratory rats with induced PMS-like conditions ## What they did Researchers randomly divided laboratory rats into three groups: normal, rats with induced PMS-like symptoms, and rats with induced PMS-like symptoms given Baixiangdan capsule at 10 g per kg of body weight daily for 5 days. They measured expression and location of a brain receptor called GABA(A) receptor beta2 in the hippocampus using microscopy and laboratory tests. ## What they found Compared to normal rats, PMS-model rats had significantly higher GABA(A) receptor beta2 expression with more concentrated distribution. Rats given Baixiangdan showed marked decreases in receptor expression and behavioral scores compared to untreated PMS-model rats. ## What it means for you This study suggests one possible brain mechanism in PMS might involve high expression of this specific receptor, and the herb appeared to normalize this. However, this is an animal study in rats, not women, so we cannot assume these results apply to human PMS. 10 g/kg Daily dose of Baixiangdan 5 Days of herbal medicine treatment ## About the study Original title [Effects of Baixiangdan capsule on location and expression levels of GABA(A) receptor beta2 subunit in hippocampus of PMS model rats with liver-qi invasion] Authors Chen Z, Sun S, Zhang H Journal Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica Year 2010 Study design Randomised trial What was tested Baixiangdan capsule at 10 g per kg of body weight daily for 5 days Read the paper [doi.org/10.4268/cjcmm20101120](https://doi.org/10.4268/cjcmm20101120) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Systematic review, 2026 Which traditional Chinese medicine treatments work best for PMS? Randomised trial, 2025 Do essential oils reduce PMS symptoms? Randomised trial, 2025 Which is more effective for PMS - Vitagnus, soy, or both together? Randomised trial, 2025 Does the PMSoff supplement help PMS and PMDD symptoms? Randomised trial, 2024 Is Jiawei Xiaoyao pill effective and safe for treating premenstrual syndrome? Randomised trial, 2024 Is Ganyushu Granule effective and safe for premenstrual syndrome? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗