--- title: Does an oral contraceptive with drospirenone reduce premenstrual worsening of Meniere's disease? description: Yes. The oral contraceptive combined with rehabilitation significantly improved dizziness and balance over 6 months, with the contraceptive group showing much url: https://niyora.com/research/papers/effects-of-combined-oral-contraception-containing-drospirenone-on-premenstrual-2018/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does an oral contraceptive with drospirenone reduce premenstrual worsening of Meniere's disease? Randomised trial, 2018 # Does an oral contraceptive with drospirenone reduce premenstrual worsening of Meniere's disease? Yes. The oral contraceptive combined with rehabilitation significantly improved dizziness and balance over 6 months, with the contraceptive group showing much better symptom improvement than rehabilitation alone. Early or limited evidence 42 premenopausal women with Meniere's disease that worsened during the premenstrual phase. ## What they did A non-randomized controlled study of 42 women with Meniere's disease (inner-ear condition causing dizziness, hearing loss, tinnitus) that worsened before their period. 16 women took an oral contraceptive with drospirenone plus rehabilitation; 20 did rehabilitation alone. Balance and symptom distress were measured at baseline, 3 months, and 6 months. ## What they found At 6 months, the oral contraceptive plus rehabilitation group had a distress score of 39.2 ± 3.8 compared to 68.8 ± 3.6 in the rehabilitation-alone group (p<0.001). Balance improvements were also significantly better in the contraceptive group at 3 and 6 months. ## What it means for you This oral contraceptive may reduce premenstrual flare-ups of Meniere's disease, possibly by preventing fluid buildup in the inner ear. However, this only applies to women whose Meniere's symptoms worsen before their period. The study wasn't randomized and was small, so stronger evidence is needed. 39.2 vs 68.8 distress score at 6 months (contraceptive vs rehabilitation) p<0.001 statistical significance 42 women studied ## About the study Original title Effects of combined oral contraception containing drospirenone on premenstrual exacerbation of Meniere's disease: Preliminary study Authors Caruso S, Mauro D, Maiolino L et al. Journal European journal of obstetrics, gynecology, and reproductive biology Year 2018 Study design Randomised trial What was tested 20 microgram ethinylestradiol with 3 mg drospirenone oral contraceptive in continuous regimen combined with rehabilitation therapy. Read the paper [doi.org/10.1016/j.ejogrb.2018.03.015](https://doi.org/10.1016/j.ejogrb.2018.03.015) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual exacerbation (PME)](https://niyora.com/research/topics/condition-pme/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Oral contraceptives and drospirenone](https://niyora.com/research/topics/treatment-hormonal-contraceptives/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Study, 2005 Do women with depression experience worsening of symptoms before their period? Randomised trial, 1992 Do different types of birth control pills work differently for PMS? Randomised trial, 2017 Does adding birth control to antidepressants help depression that worsens before your period? Review, 2024 What do brain wave patterns show about PMS and PMDD? Systematic review, 2024 What are the best treatments for PMDD and PMS? Systematic review, 2023 What hormonal treatments have been tested for PMDD, menstrual migraine, and catamenial epilepsy? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗