--- title: Does curcumin with piperine reduce PMS symptoms by lowering inflammation? description: Curcumin combined with piperine significantly reduced a specific immune marker (IgE) related to inflammation, but did not change other immune markers. The eff url: https://niyora.com/research/papers/effects-of-curcumin-piperine-supplementation-on-systemic-immunity-in-young-women-2022/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does curcumin with piperine reduce PMS symptoms by lowering inflammation? Randomised trial, 2022 # Does curcumin with piperine reduce PMS symptoms by lowering inflammation? Curcumin combined with piperine significantly reduced a specific immune marker (IgE) related to inflammation, but did not change other immune markers. The effect on PMS symptoms was not directly measured. Strong study design 80 women with both PMS and dysmenorrhea (painful periods) ## What they did 80 women with PMS and dysmenorrhea (40 curcumin, 40 placebo) took 500 mg curcuminoid plus piperine or placebo daily from 7 days before to 3 days after menstruation for 3 menstrual cycles. Blood samples measured immune markers (IgE, IL-10, IL-12). ## What they found Curcumin plus piperine significantly reduced mean serum IgE levels, declining from 223.6±258.7 to 161.3±240.7 IU/mL (P = 0.001). The placebo group showed no significant change in IgE. Neither curcumin nor placebo caused significant changes in IL-10 or IL-12 immune markers. ## What it means for you Curcumin with piperine may reduce one immune marker (IgE) related to inflammation in women with PMS and dysmenorrhea. However, it did not affect other measured immune markers. The study did not directly measure whether PMS or period pain symptoms improved. More research with higher doses and longer treatment is needed to confirm findings and measure actual symptom improvement. 80 women studied 500 mg curcumin-piperine daily 3 menstrual cycles of treatment ## About the study Original title Effects of curcumin-piperine supplementation on systemic immunity in young women with premenstrual syndrome and dysmenorrhea: A randomized clinical trial Authors Bahrami A, Mohammadifard M, Rajabi Z et al. Journal European journal of obstetrics, gynecology, and reproductive biology Year 2022 Study design Randomised trial Participants 40 What was tested 500 mg curcumin plus piperine daily from 7 days before to 3 days after menstruation for 3 menstrual cycles Open access Yes Read the paper [doi.org/10.1016/j.ejogrb.2022.09.021](https://doi.org/10.1016/j.ejogrb.2022.09.021) Original abstract Introduction: Premenstrual syndrome (PMS) and primary dysmenorrhea (PD) are common gynecological complications and there is evidence that inflammation may be an important factor in their etiology. There is a relationship between PMS and PD with susceptibility to allergic disorders. We aimed to assess the effect of curcumin co-administered with piperine on serum IL-10, IL-12 and IgE levels in patients with PD and PMS. Materials and methods: A sample of 80 patients were recruited to this triple-blind, placebo-controlled clinical trial. Participants were randomly allocated to curcumin (n = 40) and control groups (n = 40). Each participant received one capsule (500 mg of curcuminoid plus piperine, or placebo) daily, from 7 days before until 3 days after menstruation for three consecutive menstrual cycles. Results: Serum IgE, IL-10 and IL-12 levels were quantified by using an ELISA kit. No significant differences were found between the two groups at baseline, including: age, BMI, and dietary intakes (P > 0.05). Curcumin + piperine treatment was associated with a significant reduction in the mean serum levels of IgE [from 223.6 ± 258.7 IU/mL to 161.3 ± 240.7; P = 0.001]; but there were no significant changes in the placebo group (P = 0.12). Serum concentrations of IL-10 and IL-12 before and after the trial period did not differ significantly between the two groups (P > 0.05). Conclusion: Curcumin plus piperine might be have positive effect on serum IgE levels with no significant changes on serum IL-10 and IL-12 in healthy young women with PMS and PD. Studies with higher doses and longer durations of treatment with curcumin are required to confirm these findings. Reproduced under CC-BY. ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Dysmenorrhea and period pain](https://niyora.com/research/topics/condition-dysmenorrhea/)[Diet and nutrition](https://niyora.com/research/topics/treatment-diet/)[Curcumin and turmeric](https://niyora.com/research/topics/treatment-curcumin/)[Adolescents and young people](https://niyora.com/research/topics/life-area-adolescents/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Randomised trial, 2024 Does curcumin-piperine combination improve antioxidant activity in women with PMS and period pain? Randomised trial, 2023 Does curcumin help with sleep problems in women with PMS and period pain? Randomised trial, 2021 Does curcumin help with PMS and period pain? Survey study, 2020 Is period pain common in Polish women and what causes it? Case-control study, 2020 Does height affect menstrual patterns in adolescent girls? Cohort study, 2019 How do exercise, diet and weight affect menstrual problems? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗