---
title: Does a Chinese herbal medicine (Jingqianshu granule) help PMS by changing serotonin signaling in the brain?
description: In a study of PMS model rats, the herbal medicine increased serotonin receptor expression in key brain areas. However, this is an animal study and cannot be d
url: https://niyora.com/research/papers/effects-of-jingqianshu-granule-on-expression-of-5-ht-1a-r-of-pms-model-rats-with-2011/
---

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- Does a Chinese herbal medicine (Jingqianshu granule) help PMS by changing serotonin signaling in the brain?

Non-randomised trial, 2011

# Does a Chinese herbal medicine (Jingqianshu granule) help PMS by changing serotonin signaling in the brain?

In a study of PMS model rats, the herbal medicine increased serotonin receptor expression in key brain areas. However, this is an animal study and cannot be directly applied to humans with PMS.

 Early or limited evidence

Rats with experimentally-induced PMS model

## What they did

Rats with an experimentally-induced PMS model (created by limb bandaging) were treated with Jingqianshu granule. Researchers tested the rats' behavior with an open-field test and measured serotonin receptor expression in brain tissue using molecular techniques.

## What they found

After treatment with the herbal medicine, open-field test scores, serotonin receptor mRNA, and serotonin receptor protein expression in the hippocampus and hypothalamus all increased significantly.

## What it means for you

This animal study suggests the herbal medicine may work by increasing serotonin signaling in specific brain regions. However, findings from animal studies cannot be directly applied to human PMS, and the study did not include a control group for comparison.

2

brain regions studied (hippocampus, hypothalamus)

## About the study

Original title [Effects of jingqianshu granule on expression of 5-HT(1A)R of PMS model rats with liver-qi stagnation] Authors Su Y, Xue L Journal Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica Year 2011 Study design Non-randomised trial What was tested Jingqianshu granule (Chinese herbal medicine) Read the paper [doi.org/10.4268/cjcmm20112424](https://doi.org/10.4268/cjcmm20112424)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/)

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