--- title: Does PMS50 supplementation reduce psychological symptoms of premenstrual syndrome? description: Yes, it helped several psychological symptoms like mood, anxiety, and irritability compared to placebo. The study was small, so we need larger trials to be su url: https://niyora.com/research/papers/effects-of-pms50-supplementation-on-psychological-symptoms-of-students-with-2022/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does PMS50 supplementation reduce psychological symptoms of premenstrual syndrome? Randomised trial, 2022 # Does PMS50 supplementation reduce psychological symptoms of premenstrual syndrome? Yes, it helped several psychological symptoms like mood, anxiety, and irritability compared to placebo. The study was small, so we need larger trials to be sure. Moderate study design 50 university students in Iran with moderate to severe PMS ## What they did Double-blind randomized trial where 50 university students in Iran with moderate to severe PMS took either 550 mg per day of PMS50 or placebo for one week before their period until the end of their period, for three consecutive cycles. Researchers measured psychological symptoms before and after. ## What they found The PMS50 group had significant improvements in depression, anger, hopelessness, desire to be alone, mood swings, irritability, anxiety, and poor concentration compared to placebo. Restlessness decreased in both groups equally. Low self-esteem, appetite changes, and food cravings dropped in both groups but were not significantly different between them. ## What it means for you PMS50 may help mood and anxiety symptoms, but the study was small (25 women per group) and conducted in one country, so results may not apply to everyone. 25 women in treatment group 25 women in placebo group 3 consecutive menstrual cycles ## About the study Original title Effects of PMS50 supplementation on psychological symptoms of students with premenstrual syndrome Authors Sadeghi F, Javid AZ, Nazarinasab M et al. Journal International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Year 2022 Study design Randomised trial Participants 25 What was tested 550 mg per day of PMS50 Read the paper [doi.org/10.1002/ijgo.13703](https://doi.org/10.1002/ijgo.13703) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Irritability and anger](https://niyora.com/research/topics/symptom-irritability-anger/)[Appetite and food cravings](https://niyora.com/research/topics/symptom-food-cravings/)[Diet and nutrition](https://niyora.com/research/topics/treatment-diet/)[Students and academic performance](https://niyora.com/research/topics/life-area-education/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Study, 2026 What are premenstrual syndrome and premenstrual dysphoric disorder? Randomised trial, 2021 Does hypnotherapy reduce pain and emotional distress in women with PMDD? Randomised trial, 1995 Is paroxetine better than other antidepressants for treating severe PMS? Survey study, 2026 Does eating more ultra-processed food make PMS symptoms worse? Survey study, 2026 How common is PMDD in Russian medical students, and what are its symptoms? Survey study, 2017 Are PMS symptoms linked to mood disorders and personality? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗