--- title: Does a supplement with Rhodiola, Vitex, and vitamin B6 reduce PMS? description: The supplement improved mood and antioxidant protection in women taking it, but the study could not tell if this was better than placebo because both groups i url: https://niyora.com/research/papers/effects-of-the-premen-calm-in-the-management-of-the-premenstrual-syndrome-a-2024/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does a supplement with Rhodiola, Vitex, and vitamin B6 reduce PMS? Randomised trial, 2024 # Does a supplement with Rhodiola, Vitex, and vitamin B6 reduce PMS? The supplement improved mood and antioxidant protection in women taking it, but the study could not tell if this was better than placebo because both groups improved similarly. Early or limited evidence 42 women with premenstrual syndrome ## What they did A randomized, double-blind, placebo-controlled pilot study. 42 women with PMS took either PREMEN-CALM supplement (containing GABA, Rhodiola, Vitex, vitamin B6, and melatonin) or placebo for 3 months. Researchers measured antioxidants, inflammation, body composition, sleep quality, mood, quality of life, and menstrual cycle features before and after. ## What they found The supplement group showed significant improvement in antioxidant status and mood compared to baseline. However, when comparing the supplement group directly to the placebo group, there were no statistical differences, suggesting a placebo effect. ## What it means for you The supplement may help PMS symptoms through antioxidant and mood effects, but a placebo effect was likely. This was a small pilot study, so larger trials are needed before recommending it for PMS. 42 women studied 21 in supplement group 3 months treatment duration ## About the study Original title Effects of the PREMEN-CALM® in the Management of the Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Pilot Study Authors Herrera A, Al Adib M, Rodríguez AB et al. Journal Journal of dietary supplements Year 2024 Study design Randomised trial Participants 42 What was tested PREMEN-CALM (GABA, Rhodiola rosea, Vitex agnus-castus, vitamin B6, melatonin) for 3 months Read the paper [doi.org/10.1080/19390211.2023.2301398](https://doi.org/10.1080/19390211.2023.2301398) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Sleep and insomnia](https://niyora.com/research/topics/symptom-sleep/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Oral contraceptives and drospirenone](https://niyora.com/research/topics/treatment-hormonal-contraceptives/)[Diet and nutrition](https://niyora.com/research/topics/treatment-diet/)[Vitamin B6](https://niyora.com/research/topics/treatment-vitamin-b6/)[Vitex agnus-castus (chasteberry)](https://niyora.com/research/topics/treatment-vitex/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/)[Quality of life and daily functioning](https://niyora.com/research/topics/life-area-quality-of-life/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Review, 2023 Can herbs and supplements help with PMS symptoms? Review, 2015 What do we know about PMS and PMDD and how are they treated? Randomised trial, 2010 What treatments work for premenstrual syndrome? Systematic review, 2007 What treatments work for premenstrual syndrome? Review, 2025 Do yoga and dietary changes help with PMS symptoms? Study, 2026 How can lifestyle changes help reduce premenstrual syndrome? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗