--- title: Does Vitex help PMS symptoms? | Niyora description: Yes, Vitex reduced PMS symptoms, with 91 percent of women improving by the third cycle. However, without a control group, we cannot be certain Vitex itself ca url: https://niyora.com/research/papers/efficacy-and-safety-of-vitex-agnus-castus-extract-for-treatment-of-premenstrual-2014/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does Vitex help PMS symptoms? Non-randomised trial, 2014 # Does Vitex help PMS symptoms? Yes, Vitex reduced PMS symptoms, with 91 percent of women improving by the third cycle. However, without a control group, we cannot be certain Vitex itself caused the improvement. Early or limited evidence 69 Japanese women with PMS, aged 18-44. ## What they did A single-arm study of 69 Japanese women with PMS who took 20 mg of Vitex extract once daily for three menstrual cycles and tracked ten PMS symptoms on a pain scale. ## What they found Symptom scores dropped significantly after the first cycle and continued decreasing. By the third cycle, 91.0 percent of women showed little or no symptoms. Eight women had minor adverse events. ## What it means for you Vitex appears to reduce PMS symptoms in Japanese women. However, this study had no control group to compare against, so we cannot be certain the improvement was due to the supplement itself rather than placebo or other factors. 69 Women treated 20 mg Daily dose of Vitex 91.0% With good improvement by cycle 3 ## About the study Original title Efficacy and safety of Vitex agnus-castus extract for treatment of premenstrual syndrome in Japanese patients: a prospective, open-label study Authors Momoeda M, Sasaki H, Tagashira E et al. Journal Advances in therapy Year 2014 Study design Non-randomised trial Participants 3 What was tested Prefemin (Vitex agnus-castus extract), 20 mg once daily. Read the paper [doi.org/10.1007/s12325-014-0106-z](https://doi.org/10.1007/s12325-014-0106-z) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Irritability and anger](https://niyora.com/research/topics/symptom-irritability-anger/)[Vitex agnus-castus (chasteberry)](https://niyora.com/research/topics/treatment-vitex/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Randomised trial, 2012 Does Vitex agnus castus work for PMS, and what dose is best? Randomised trial, 2001 Does agnus castus (Vitex) fruit extract reduce premenstrual syndrome symptoms? Survey study, 2025 Can a chatbot help monitor PMS symptoms over time? Randomised trial, 2012 Does Vitex agnus castus help women with PMS? Survey study, 2025 Can a plant-based supplement reduce PMS symptoms? Survey study, 2024 What do pharmacy students know about using herbs for PMS? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗