--- title: Does a supplement with Vitex, vitamin B6, and magnesium reduce PMS symptoms? description: Yes. The supplement was more effective than standard therapy alone at reducing PMS symptoms and improving quality of life, with the best results when combined url: https://niyora.com/research/papers/efficacy-and-tolerability-evaluation-of-a-nutraceutical-composition-containing-2023/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does a supplement with Vitex, vitamin B6, and magnesium reduce PMS symptoms? Non-randomised trial, 2023 # Does a supplement with Vitex, vitamin B6, and magnesium reduce PMS symptoms? Yes. The supplement was more effective than standard therapy alone at reducing PMS symptoms and improving quality of life, with the best results when combined with standard treatment. Early or limited evidence 64 women with PMS of varying severity ## What they did Researchers studied 64 women with PMS in three groups: 23 received standard therapy only, 20 received a nutraceutical supplement (Ezedayz tablets containing Vitex agnus-castus extract, vitamin B6, and magnesium) for 90 days, and 21 received both together. They measured PMS symptoms like backache, cramps, joint or muscle pain, and headache using a pain scale and assessed quality of life. ## What they found The nutraceutical supplement was effective in reducing the severity of PMS symptoms and improving quality of life. The supplement alone provided greater relief from PMS symptoms compared to standard therapy alone. When combined with standard therapy, the improvement was even greater. Quality-of-life improvements were also larger in subjects treated with the nutraceutical alone or in combination with standard therapy compared to standard therapy alone. ## What it means for you This supplement may help reduce PMS pain and improve your quality of life, especially when combined with other treatments. However, this was a small study without randomization and results were self-reported, so more research is needed. The study did not compare this supplement to other supplements or to placebo. 90 days duration of supplement treatment Vitex, B6, Mg supplement ingredients 64 total participants ## About the study Original title Efficacy and Tolerability Evaluation of a Nutraceutical Composition Containing Vitex agnus-castus Extract (EVX40™), Pyridoxine, and Magnesium in Premenstrual Syndrome: A Real-World, Interventional, Comparative Study Authors Sureja VP, Kheni DB, Dubey VP et al. Journal Cureus Year 2023 Study design Non-randomised trial Participants 23 What was tested Ezedayz tablets containing Vitex agnus-castus extract, vitamin B6, and magnesium for 90 days Open access Yes Read the paper [doi.org/10.7759/cureus.42832](https://doi.org/10.7759/cureus.42832) Original abstract Background Pre-menstrual syndrome (PMS) is a condition associated with altered hormone levels during the menstrual phase of females and is characterised by physical, emotional, and behavioural symptoms that have a negative impact on the quality of life of females. The symptoms of PMS may vary between individuals, but the major complication is pain, especially during menstrual days. The current treatment strategy involves the use of hormonal therapies and analgesics for symptomatic relief, but these therapies have a risk of potential side effects. The use of herbal and nutraceutical supplements in PMS conditions is increasing due to their long-term safety and proven efficacy. The current real-world study aimed to evaluate the efficacy and tolerability of Ezedayz ® tablets containing Vitex agnus-castus extract (EVX40™), vitamin B6, and magnesium in PMS subjects. Methodology A real-world, open-label study was conducted involving 64 participants with varied severity of PMS symptoms. Participants were categorised into Group A (N=23) receiving standard therapies, Group B (N=20) receiving Ezedayz ® tablets, or Group C (N=21) receiving standard and Ezedayz ® therapy. Standard therapies were provided as per physician supervision, and Ezedayz ® tablets were given for 90 days. All subjects were evaluated on core symptoms of PMS like menstrual backache, menstrual cramps, joint or muscle pain, and headache using the numerical rating scale (NRS), and quality-of-life (QoL) was evaluated using a QoL questionnaire. A spontaneous reporting methodology was used to evaluate the tolerability of the therapies provided. Statistical analysis was performed as per the statistical plan. A p-value of Vitex agnus-castus extract, vitamin B6, and magnesium is effective in reducing the severity of PMS symptoms and improving the quality of life of PMS subjects. The nutraceutical therapy provided greater relief from PMS symptoms compared to standard therapy alone, and this effect was augmented when the nutraceutical therapy was provided in combination with standard therapies. Similarly, the improvement in quality-of-life parameters was greater in subjects treated with nutraceuticals alone or in combination therapy. Despite the limitations of the study, the results of the current study are promising, and the nutraceutical composition (Ezedayz ® ) can be effectively used in clinical settings to control symptoms and improve the quality of life of PMS patients. Reproduced under CC-BY. ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Dysmenorrhea and period pain](https://niyora.com/research/topics/condition-dysmenorrhea/)[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Magnesium](https://niyora.com/research/topics/treatment-magnesium/)[Vitamin B6](https://niyora.com/research/topics/treatment-vitamin-b6/)[Vitex agnus-castus (chasteberry)](https://niyora.com/research/topics/treatment-vitex/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/)[Quality of life and daily functioning](https://niyora.com/research/topics/life-area-quality-of-life/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Survey study, 2026 Can changing your diet help with period and PMS symptoms like fatigue, mood swings and bloating? Review, 2025 Do herbal remedies help with menstrual and menopausal symptoms? Review, 2025 Do yoga and dietary changes help with PMS symptoms? Review, 2023 Can herbs and supplements help with PMS symptoms? Randomised trial, 2024 Does a supplement with Rhodiola, Vitex, and vitamin B6 reduce PMS? Systematic review, 2021 Does damask rose help reduce menstrual pain, headache, fatigue, anxiety, and bloating? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗