--- title: Does lasmiditan help with migraines around menstruation? | Niyora description: Lasmiditan 200 mg helped more women achieve migraine pain freedom compared to placebo. At 2 hours, 33.6% of women taking the 200 mg dose had pain relief. url: https://niyora.com/research/papers/efficacy-of-lasmiditan-for-the-acute-treatment-of-perimenstrual-migraine-2022/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does lasmiditan help with migraines around menstruation? Randomised trial, 2022 # Does lasmiditan help with migraines around menstruation? Lasmiditan 200 mg helped more women achieve migraine pain freedom compared to placebo. At 2 hours, 33.6% of women taking the 200 mg dose had pain relief. Moderate study design 303 women from two clinical trials treating perimenstrual migraine attacks ## What they did This was a pooled analysis of two randomized controlled trials (MONONOFU and CENTURION). A total of 303 women took a single dose of lasmiditan (50 mg, 100 mg, or 200 mg) or placebo and were checked for migraine pain relief up to 48 hours later. ## What they found More patients achieved migraine pain freedom with lasmiditan 200 mg versus placebo at all time points. At 2 hours, 33.6% of the 200 mg group had pain freedom compared to placebo. The 100 mg and 50 mg doses were also tested but 200 mg was the most effective. ## What it means for you Lasmiditan 200 mg appears to be a useful treatment for migraines that occur around menstruation. This analysis combined data from two trials so the evidence is reasonably strong, but it is a post-hoc analysis rather than a study designed specifically for perimenstrual migraine. 303 Women treated with lasmiditan or placebo 33.6% Achieved pain freedom at 2 hours (200 mg group) 200 mg Most effective dose tested ## About the study Original title Efficacy of lasmiditan for the acute treatment of perimenstrual migraine Authors MacGregor EA, Komori M, Krege JH et al. Journal Cephalalgia : an international journal of headache Year 2022 Study design Randomised trial Participants 303 What was tested Lasmiditan 200 mg, 100 mg, or 50 mg versus placebo (single dose) Open access Yes Read the paper [doi.org/10.1177/03331024221118929](https://doi.org/10.1177/03331024221118929) ## Topics [Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Migraine](https://niyora.com/research/topics/comorbidity-migraine/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Systematic review, 2023 What hormonal treatments have been tested for PMDD, menstrual migraine, and catamenial epilepsy? Cohort study, 2022 Can women accurately tell if they have period-related migraines, or do they need to track them? Guideline, 2021 How should migraine be managed in women, particularly menstrual migraine? Randomised trial, 2016 Does telcagepant prevent migraines during the menstrual period? Randomised trial, 2014 Does the combination of sumatriptan and naproxen sodium reduce menstrual symptoms and migraine? Randomised trial, 2005 Does sumatriptan work for migraines around the menstrual cycle? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗