---
title: Does starting hormonal contraception between ages 13 and 17 reduce premenstrual symptoms by age 18?
description: This is a planned study that has not yet been completed. No results are available yet to answer this question.
url: https://niyora.com/research/papers/estimating-the-effect-of-combined-oral-contraception-on-premenstrual-symptoms-2026/
---

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- Does starting hormonal contraception between ages 13 and 17 reduce premenstrual symptoms by age 18?

Cohort study, 2026

# Does starting hormonal contraception between ages 13 and 17 reduce premenstrual symptoms by age 18?

This is a planned study that has not yet been completed. No results are available yet to answer this question.

 Early or limited evidence

Adolescents from the Generation R Study cohort in Rotterdam, Netherlands, ages 13-18

## What they did

This is a planned study (not yet conducted) that will use the Target Trial Emulation framework with data from the Generation R Study cohort in Rotterdam, Netherlands. It will follow adolescents from ages 13-17 who do and do not start hormonal contraception and compare premenstrual symptoms at age 18.

## What they found

No results are available because this study has not yet been conducted.

## What it means for you

Once completed, this study could show whether hormonal contraception helps premenstrual symptoms in teenage girls. The main limitation is that the study has not yet been conducted.

13-17

Age range for starting hormonal contraception

18

Age when outcomes assessed

## About the study

Original title Estimating the Effect of Combined Oral Contraception on Premenstrual Symptoms among Adolescents – A Target Trial Emulation Authors Fatima El Markai, Lina Al-Hassany, Jeremy Alexander Labrecque et al. Year 2026 Study design Cohort study What was tested Hormonal contraception initiated between ages 13-17 Open access Yes Read the paper [doi.org/10.17605/osf.io/2us7t](https://doi.org/10.17605/osf.io/2us7t) Original abstract

This study aims to explore the causal relationship between hormonal contraception and premenstrual symptoms in adolescents using the Target Trial Emulation (TTE) framework. We will leverage the Generation R Study, a longitudinal population-based cohort from birth to young adulthood in Rotterdam, The Netherlands. The following research question will be answered: What is the effect of hormonal contraception initiation between ages 13 and 17 on premenstrual symptoms around the age of 18 years?

Reproduced under public-domain.

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Oral contraceptives and drospirenone](https://niyora.com/research/topics/treatment-hormonal-contraceptives/)[Adolescents and young people](https://niyora.com/research/topics/life-area-adolescents/)

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